日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies

针对 α-Dystroglycanopathies 的糖融合双特异性抗体的代谢工程

Xiaotian Zhong, Guoying Grace Yan, Apurva Chaturvedi, Xiuling Li, Yijie Gao, Mahasweta Girgenrath, Chris J Corcoran, Liz Diblasio-Smith, Edward R LaVallie, Teresse de Rham, Jing Zhou, Molica Abel, Logan Riegel, Sean K H Lim, Laird Bloom, Laura Lin, Aaron M D'Antona

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

抗 BDNF 单克隆抗体的体外亲和力优化可提高体内针对慢性疼痛状态的效力

Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Gareth Young, Kim Marquette, Sadhana Jain, Kerry Kelleher, Ting Chen, Qingcong Lin, Laird Bloom, Laura Lin, William Finlay, Rie Suzuki, Orla Cunningham

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

建立体内外相关性,筛选与有利的人体药代动力学相关的物理化学特性的单克隆抗体

Lindsay B Avery, Jason Wade, Mengmeng Wang, Amy Tam, Amy King, Nicole Piche-Nicholas, Mania S Kavosi, Steve Penn, David Cirelli, Jeffrey C Kurz, Minlei Zhang, Orla Cunningham, Rhys Jones, Brian J Fennell, Barry McDonnell, Paul Sakorafas, James Apgar, William J Finlay, Laura Lin, Laird Bloom, Denise

Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources

噬菌体展示:一种从替代免疫源生成高特异性亲和试剂的强大技术

William J J Finlay, Laird Bloom, Joanne Grant, Edward Franklin, Deirdre Ní Shúilleabháin, Orla Cunningham

IL-21 receptor is critical for the development of memory B cell responses

IL-21 受体对于记忆 B 细胞反应的发展至关重要

Andrew L Rankin, Heather MacLeod, Sean Keegan, Tatyana Andreyeva, Leslie Lowe, Laird Bloom, Mary Collins, Cheryl Nickerson-Nutter, Deborah Young, Heath Guay

Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources

噬菌体展示:一种从替代免疫源生成高特异性亲和力试剂的强大技术

William J J Finlay, Laird Bloom, Orla Cunningham

Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

评估候选治疗性抗 IL21R 抗体的激动剂潜力

Yongjing Guo, Andrew A Hill, Renee C Ramsey, Frederick W Immermann, Christopher Corcoran, Deborah Young, Edward R Lavallie, Mark Ryan, Theresa Bechard, Richard Pfeifer, Garvin Warner, Marcia Bologna, Laird Bloom, Margot O'Toole

In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

优化的抗 IL-21R 抗体在小鼠狼疮模型中的体外效力、药代动力学特征和药理活性

Yulia Vugmeyster, Heath Guay, Pamela Szklut, Ming D Qian, Macy Jin, Angela Widom, Vikki Spaulding, Frann Bennett, Leslie Lowe, Tatyana Andreyeva, David Lowe, Steven Lane, George Thom, Viia Valge-Archer, Davinder Gill, Deborah Young, Laird Bloom