Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym
利用定量系统毒理学软件平台DILIsym对健康成人过量服用缓释和速释制剂后对乙酰氨基酚的药代动力学和肝脏生物标志物进行建模和模拟。
期刊:Cpt-Pharmacometrics & Systems Pharmacology
影响因子:3
doi:10.1002/psp4.13304
Beaudoin, James J; Yang, Kyunghee; Howell, Brett A; Kenz, Zackary; Lakhani, Vinal V; Woodhead, Jeffrey L; Lai, John C K; Gelotte, Cathy K; Sista, Sury; Atillasoy, Evren