A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells
曲妥珠单抗与17-AAG联合用药可增强ErbB2过表达乳腺癌细胞中ErbB2的泛素化和溶酶体途径依赖性降解，并增强其细胞毒性。
期刊:Cancer Biology & Therapy
影响因子:4.6
doi:10.4161/cbt.7.10.6585
Raja, Srikumar M; Clubb, Robert J; Bhattacharyya, Mitra; Dimri, Manjari; Cheng, Hao; Pan, Wei; Ortega-Cava, Cesar; Lakku-Reddi, Alagarsamy; Naramura, Mayumi; Band, Vimla; Band, Hamid
肿瘤
表观遗传
肿瘤免疫
泛素化
乳腺癌
细胞生物学
毒理研究
