日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

微生物色氨酸代谢产物吲哚作用于胃肠道,通过增强GLP-1分泌和L细胞分化,改善糖尿病小鼠模型的葡萄糖稳态。

Phuah, Phyllis; Norton, Mariana; Cheng, Sijing; Roberts, Anna G; Pirri, Daniela; Meyer, Leah; Chung, Pei-En; Dunsterville, Cecilia; Karwowski, Rafal; Lam, Brian Y H; Otsubo, Emile; Aleksashina, Sofia; Gribble, Fiona M; Reimann, Frank; Hanyaloglu, Aylin C; Yeo, Giles S H; Bewick, Gavin A; Jones, Ben; Owen, Bryn; Murphy, Kevin G

Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance

跨物种研究表明,黑皮质素3受体在青春期发育调控中的作用比能量平衡更强。

Duckett, Katie; McClellan, Alyce; Corbin, Laura J; Cimino, Irene; Elhakeem, Ahmed; Goncalves Soares, Ana; Williamson, Alice; Cross, Eloise; Fairhurst-Hunter, Zammy; Petrovski, Slavé; Rimmington, Debra; Alegre-Díaz, Jesús; Berumen, Jaime; Kuri-Morales, Pablo; Tapia-Conyer, Roberto; Mokrosinski, Jacek; Farooqi, I Sadaf; Rasheed, Asif; Saleheen, Danish; Butterworth, Adam S; Timpson, Nicholas J; Coll, Anthony P; Raffan, Eleanor; Lam, Brian Y H; O'Rahilly, Stephen

Author Correction: A comprehensive spatio-cellular map of the human hypothalamus

作者更正:人类下丘脑的综合空间细胞图谱

Tadross, John A; Steuernagel, Lukas; Dowsett, Georgina K C; Kentistou, Katherine A; Lundh, Sofia; Porniece, Marta; Klemm, Paul; Rainbow, Kara; Hvid, Henning; Kania, Katarzyna; Polex-Wolf, Joseph; Knudsen, Lotte Bjerre; Pyke, Charles; Perry, John R B; Lam, Brian Y H; Brüning, Jens C; Yeo, Giles S H

A comprehensive spatio-cellular map of the human hypothalamus.

人类下丘脑的综合空间细胞图谱

Tadross John A, Steuernagel Lukas, Dowsett Georgina K C, Kentistou Katherine A, Lundh Sofia, Porniece Marta, Klemm Paul, Rainbow Kara, Hvid Henning, Kania Katarzyna, Polex-Wolf Joseph, Knudsen Lotte Bjerre, Pyke Charles, Perry John R B, Lam Brian Y H, Brüning Jens C, Yeo Giles S H

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans

犬类全基因组关联研究发现 DENND1B 是犬类和人类的肥胖基因。

Wallis, Natalie J; McClellan, Alyce; Mörseburg, Alexander; Kentistou, Katherine A; Jamaluddin, Aqfan; Dowsett, Georgina K C; Schofield, Ellen; Morros-Nuevo, Anna; Saeed, Sadia; Lam, Brian Y H; Sumanasekera, Natasha T; Chan, Justine; Kumar, Sambhavi S; Zhang, Rey M; Wainwright, Jodie F; Dittmann, Marie; Lakatos, Gabriella; Rainbow, Kara; Withers, David; Bounds, Rebecca; Ma, Marcella; German, Alexander J; Ladlow, Jane; Sargan, David; Froguel, Philippe; Farooqi, I Sadaf; Ong, Ken K; Yeo, Giles S H; Tadross, John A; Perry, John R B; Gorvin, Caroline M; Raffan, Eleanor

The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system.

苯丙胺的代谢和心血管效应部分是由中枢黑皮质素系统介导的

Simonds Stephanie E, Pryor Jack T, Lam Brian Y H, Dowsett Georgina K, Mustafa Tomris, Munder Astrid, Elysee Kayla, Balland Eglantine, Cowley Lachlan O, Yeo Giles S H, Lawrence Andrew, Spanswick David C, Cowley Michael A

Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health

双向孟德尔随机化表明循环支链氨基酸与代谢健康之间存在因果关系

Jia, Raina Y; Chen, Jian-Hua; Lockhart, Sam; Lam, Brian Y H; Kentistou, Katherine A; Zhao, Yajie; Gardner, Eugene J; Perry, John R B; O'Rahilly, Stephen; Day, Felix R; Ong, Ken K

Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors

HTRA1、SGTB 和 RBM12 中的罕见变异会增加动脉粥样硬化性心血管疾病的风险,且这种风险独立于传统心血管危险因素。

Lockhart, Sam M; Puri, Anuradhika; Zhao, Yajie; Saudek, Vladimir; Gardner, Eugene J; Kentistou, Katherine A; Lam, Brian Y H; Day, Felix R; O'Rahilly, Stephen; Perry, John R B; Ong, Ken K; Jackrel, Meredith E

Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study

英国生物银行人群研究中罕见编码变异对严重早发性肥胖基因的影响

Jia, Raina Y; Lockhart, Sam; Lam, Brian Y H; Zhao, Yajie; Kentistou, Katherine A; Gardner, Eugene J; Farooqi, I Sadaf; O'Rahilly, Stephen; Day, Felix R; Ong, Ken K; Perry, John R B

Fasting pancreatic polypeptide predicts incident microvascular and macrovascular complications of type 2 diabetes: An observational study

空腹胰多肽可预测2型糖尿病微血管和大血管并发症的发生:一项观察性研究

Sam, Amir H; Buckley, Adam J; Lam, Brian Y H; Bewick, Gavin A; Bech, Paul R; Meeran, Karim; Barakat, Maha T; Bloom, Stephen R; Yeo, Giles S H; Lessan, Nader G; Murphy, Kevin G