日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease

针对亨廷顿氏病躯体不稳定性治疗的 CAG 重复阈值

Sarah G Aldous, Edward J Smith, Christian Landles, Georgina F Osborne, Maria Cañibano-Pico, Iulia M Nita, Jemima Phillips, Yongwei Zhang, Bo Jin, Marissa B Hirst, Caroline L Benn, Brian C Bond, Winfried Edelmann, Jonathan R Greene, Gillian P Bates

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays

突变型亨廷顿蛋白随CAG重复序列扩增而减少:对治疗和生物测定的启示

Landles, Christian; Osborne, Georgina F; Phillips, Jemima; Canibano-Pico, Maria; Nita, Iulia M; Ali, Nadira; Bobkov, Konstantin; Greene, Jonathan R; Sathasivam, Kirupa; Bates, Gillian P

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches

通过分子和组织学方法早期检测 zQ175 脑中外显子 1 亨廷顿蛋白的聚集

Edward J Smith, Kirupa Sathasivam, Christian Landles, Georgina F Osborne, Michael A Mason, Casandra Gomez-Paredes, Bridget A Taxy, Rebecca E Milton, Anne Ast, Franziska Schindler, Chuangchuang Zhang, Wenzhen Duan, Erich E Wanker, Gillian P Bates

Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics

人类 HTT mRNA 的替代加工对亨廷顿氏病治疗具有重要意义

Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer, Rebecca E Milton, Georgina F Osborne, Edward J Smith, Samuel T Jones, Marie K Bondulich, Emily C E Danby, Jemima Phillips, Bridget A Taxy, Holly B Kordasiewicz, Gillian P Bates

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease

相关光学和电子显微镜表明,突变亨廷顿蛋白会扰乱症状前亨廷顿病中的内溶酶体途径

Ya Zhou, Thomas R Peskett, Christian Landles, John B Warner, Kirupa Sathasivam, Edward J Smith, Shu Chen, Ronald Wetzel, Hilal A Lashuel, Gillian P Bates #, Helen R Saibil #

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms

在三种技术平台上开发用于检测可溶性和聚集性亨廷顿蛋白的新型生物测定方法

Landles, Christian; Milton, Rebecca E; Jean, Alexandre; McLarnon, Stuart; McAteer, Sean J; Taxy, Bridget A; Osborne, Georgina F; Zhang, Chuangchuang; Duan, Wenzhen; Howland, David; Bates, Gillian P

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

TBK1 磷酸化突变型亨廷顿蛋白并抑制其在亨廷顿病模型中的聚集和毒性

Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan Auwerx, Christian Landles, Gillian P Bates, Malvindar K Singh-Bains, Mike Dragunow, Maurice A Curtis, Richard Lm Faull, Christopher A Ross, Andrea Caricasole, Hilal A Lashuel

Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model

亨廷顿蛋白聚集体的亚细胞定位和形成与亨廷顿病模型中的症状出现和进展相关

Christian Landles, Rebecca E Milton, Nadira Ali, Rachel Flomen, Michael Flower, Franziska Schindler, Casandra Gomez-Paredes, Marie K Bondulich, Georgina F Osborne, Daniel Goodwin, Grace Salsbury, Caroline L Benn, Kirupa Sathasivam, Edward J Smith, Sarah J Tabrizi, Erich E Wanker, Gillian P Bates

Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

亨廷顿病基因敲入小鼠的表型出现与突变亨廷顿基因的不完全剪接有关

Franich Nicholas R, Hickey Miriam A, Zhu Chunni, Osborne Georgina F, Ali Nadira, Chu Tiffany, Bove Nicholas H, Lemesre Vincent, Lerner Renata P, Zeitlin Scott O, Howland David, Neueder Andreas, Landles Christian, Bates Gillian P, Chesselet Marie-Francoise