日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models

靶向外显子1的miRNA可降低亨廷顿病模型中致病性外显子1 HTT蛋白的表达。

Sogorb-Gonzalez, Marina; Landles, Christian; Caron, Nicholas S; Stam, Anouk; Osborne, Georgina; Hayden, Michael R; Howland, David; van Deventer, Sander; Bates, Gillian P; Vallès, Astrid; Evers, Melvin

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays

突变型亨廷顿蛋白随CAG重复序列扩增而减少:对治疗和生物测定的启示

Landles, Christian; Osborne, Georgina F; Phillips, Jemima; Canibano-Pico, Maria; Nita, Iulia M; Ali, Nadira; Bobkov, Konstantin; Greene, Jonathan R; Sathasivam, Kirupa; Bates, Gillian P

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms

在三种技术平台上开发用于检测可溶性和聚集性亨廷顿蛋白的新型生物测定方法

Landles, Christian; Milton, Rebecca E; Jean, Alexandre; McLarnon, Stuart; McAteer, Sean J; Taxy, Bridget A; Osborne, Georgina F; Zhang, Chuangchuang; Duan, Wenzhen; Howland, David; Bates, Gillian P

Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

亨廷顿病基因敲入小鼠的表型出现与突变亨廷顿基因的不完全剪接有关

Franich Nicholas R, Hickey Miriam A, Zhu Chunni, Osborne Georgina F, Ali Nadira, Chu Tiffany, Bove Nicholas H, Lemesre Vincent, Lerner Renata P, Zeitlin Scott O, Howland David, Neueder Andreas, Landles Christian, Bates Gillian P, Chesselet Marie-Francoise

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

人类胚胎的自然选择:子宫内膜蜕膜化受损会破坏胚胎与母体的相互作用,并导致反复流产

Salker, Madhuri; Teklenburg, Gijs; Molokhia, Mariam; Lavery, Stuart; Trew, Geoffrey; Aojanepong, Tepchongchit; Mardon, Helen J; Lokugamage, Amali U; Rai, Raj; Landles, Christian; Roelen, Bernard A J; Quenby, Siobhan; Kuijk, Ewart W; Kavelaars, Annemieke; Heijnen, Cobi J; Regan, Lesley; Macklon, Nick S; Brosens, Jan J

Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

人类胚胎的自然选择:蜕膜化的子宫内膜基质细胞在着床时作为胚胎质量的传感器

Teklenburg, Gijs; Salker, Madhuri; Molokhia, Mariam; Lavery, Stuart; Trew, Geoffrey; Aojanepong, Tepchongchit; Mardon, Helen J; Lokugamage, Amali U; Rai, Raj; Landles, Christian; Roelen, Bernard A J; Quenby, Siobhan; Kuijk, Ewart W; Kavelaars, Annemieke; Heijnen, Cobi J; Regan, Lesley; Brosens, Jan J; Macklon, Nick S

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

亨廷顿蛋白及其在亨廷顿病中的分子发病机制。分子医学评论系列之四

Landles, Christian; Bates, Gillian P