日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of tau neuronal internalization using anti-tau single domain antibodies

利用抗tau单域抗体抑制tau蛋白神经元内吞作用

Danis, Clément; Dupré, Elian; Bouillet, Thomas; Denéchaud, Marine; Lefebvre, Camille; Nguyen, Marine; Mortelecque, Justine; Cantrelle, François-Xavier; Rain, Jean-Christophe; Hanoulle, Xavier; Colin, Morvane; Buée, Luc; Landrieu, Isabelle

Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments.

PHF-1 过度磷酸化对 C 端 Tau 片段种子活性的影响

El Hajjar Léa, Boll Emmanuelle, Cantrelle François-Xavier, Bridot Clarisse, Landrieu Isabelle, Smet-Nocca Caroline

Precision proteoform design for 4R tau isoform selective templated aggregation

针对 4R tau 亚型选择性模板聚集的精确蛋白质组设计

Longhini, Andrew P; DuBose, Austin; Lobo, Samuel; Vijayan, Vishnu; Bai, Yeran; Rivera, Erica Keane; Sala-Jarque, Julia; Nikitina, Arina; Carrettiero, Daniel C; Unger, Matthew T; Sclafani, Olivia R; Fu, Valerie; Beckett, Emily R; Vigers, Michael; Buée, Luc; Landrieu, Isabelle; Shell, Scott; Shea, Joan E; Han, Songi; Kosik, Kenneth S

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

塑造阿尔茨海默病疾病修饰药物临床前开发的未来:tau蛋白传播模型的系统性综述

Basheer, Neha; Buee, Luc; Brion, Jean-Pierre; Smolek, Tomas; Muhammadi, Muhammad Khalid; Hritz, Jozef; Hromadka, Tomas; Dewachter, Ilse; Wegmann, Susanne; Landrieu, Isabelle; Novak, Petr; Mudher, Amritpal; Zilka, Norbert

Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation

4R Tau 亚型选择性模板聚集的精确蛋白质组设计

Longhini, Andrew P; DuBose, Austin; Lobo, Samuel; Vijayan, Vishnu; Bai, Yeran; Rivera, Erica Keane; Sala-Jarque, Julia; Nikitina, Arina; Carrettiero, Daniel C; Unger, Matthew; Sclafani, Olivia; Fu, Valerie; Vigers, Michael; Buee, Luc; Landrieu, Isabelle; Shell, Scott; Shea, Joan E; Han, Songi; Kosik, Kenneth S

Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools

利用化学生物学工具解析神经退行性疾病中淀粉样蛋白的结构和形成

Landrieu, Isabelle; Dupré, Elian; Sinnaeve, Davy; El Hajjar, Léa; Smet-Nocca, Caroline

NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment

SARS-CoV-2主蛋白酶的核磁共振波谱分析和基于片段的筛选鉴定出三个蛋白质热点和一个抗病毒片段

Cantrelle, François-Xavier; Boll, Emmanuelle; Brier, Lucile; Moschidi, Danai; Belouzard, Sandrine; Landry, Valérie; Leroux, Florence; Dewitte, Frédérique; Landrieu, Isabelle; Dubuisson, Jean; Deprez, Benoit; Charton, Julie; Hanoulle, Xavier

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.

tau 病理中 C1q 失调加剧、突触丢失和记忆缺陷与神经元腺苷 A2A 受体相关

Carvalho Kevin, Faivre Emilie, Pietrowski Marie J, Marques Xavier, Gomez-Murcia Victoria, Deleau Aude, Huin Vincent, Hansen Jan N, Kozlov Stanislav, Danis Clément, Temido-Ferreira Mariana, Coelho Joana E, Mériaux Céline, Eddarkaoui Sabiha, Gras Stéphanie Le, Dumoulin Mélanie, Cellai Lucrezia, Landrieu Isabelle, Chern Yijuang, Hamdane Malika, Buée Luc, Boutillier Anne-Laurence, Levi Sabine, Halle Annett, Lopes Luisa V, Blum David

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

难以捉摸的 tau 分子结构:我们能否将近期的突破转化为新的干预靶点?

Fichou, Yann; Al-Hilaly, Youssra K; Devred, François; Smet-Nocca, Caroline; Tsvetkov, Philipp O; Verelst, Joke; Winderickx, Joris; Geukens, Nick; Vanmechelen, Eugeen; Perrotin, Audrey; Serpell, Louise; Hanseeuw, Bernard J; Medina, Miguel; Buée, Luc; Landrieu, Isabelle

Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution

锌与Tau蛋白的结合影响聚集动力学和寡聚体分布

Moreira, Guilherme G; Cristóvão, Joana S; Torres, Vukosava M; Carapeto, Ana P; Rodrigues, Mário S; Landrieu, Isabelle; Cordeiro, Carlos; Gomes, Cláudio M