日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor-Initiating Cells Characterized by IFN/STAT1 Activity

谱系追踪和单细胞RNA测序揭示了乳腺癌肿瘤起始细胞中一种共同的转录状态,该状态以IFN/STAT1活性为特征。

Eric P Souto ,Ping Gong ,John D Landua ,Ramakrishnan Rajaram Srinivasan ,Abhinaya Ganesan ,Lacey E Dobrolecki ,Stephen C Purdy ,Xingxin Pan ,Michael Zeosky ,Anna Chung ,S Stephen Yi ,Heide L Ford ,Michael T Lewis

Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer

孤儿核受体4A1 (NR4A1) 和NR4A2是CD71的内源性调节因子,它们的配体可诱导乳腺癌细胞发生铁死亡。

Oany, Arafat Rahman; Upadhyay, Srijana; Tsui, Wai Ning Tiffany; Hailemariam, Amanuel; Latka, Sarah; Landua, John D; Scherer, Sandra D; Welm, Alana L; Villanueva, Hugo; Lewis, Michael T; Safe, Stephen

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by small molecules.

eIF3d 和 eIF3e 介导对缺氧的选择性翻译控制,这种控制可被小分子抑制。

Purdy Stephen C, Matlin Kate, Alderman Christopher, Baldwin Amber, Shrivastava Natasha, Sarioglu Goksu, Dutta Somnath, Webb Kristofor J, Wolin Arthur, Boulton Dillon P, Gustafson Annika, Kapali Jyoti, Landua John D, Lewis Michael T, Caino M Cecilia, Costello James C, Old William, Wang Xiang, Zhao Rui, Ford Heide L, Mukherjee Neelanjan

Advantages in orthopaedic implant infection diagnostics by additional analysis of explants

通过对取出植入物进行额外分析,在骨科植入物感染诊断中具有优势

Suda, Arnold J; Miethke, Thomas; Landua, Nadine; Obertacke, Udo

The tetravalent, bispecific properties of FS118, an anti-LAG-3/PD-L1 antibody, mediate LAG-3 shedding from CD4 + and CD8 + tumor-infiltrating lymphocytes.

FS118 是一种抗 LAG-3/PD-L1 抗体,其四价双特异性可介导 LAG-3 从 CD4 + 和 CD8 + 肿瘤浸润淋巴细胞中脱落

Reader Claire S, Liao Wenjia, Potter-Landua Beatrice J, Veyssier Christel Séguy, Seal Claire J, Brewis Neil, Morrow Michelle

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules.

eIF3d 和 eIF3e 介导对缺氧的选择性翻译控制,这种控制可被新型小分子抑制

Purdy Stephen C, Matlin Kate, Alderman Christopher, Baldwin Amber, Shrivastava Natasha, Dutta Somnath, Webb Kristofor J, Wolin Arthur, Boulton Dillon P, Kapali Jyoti, Landua John D, Lewis Michael T, Caino M Cecilia, Costello James C, Old William, Wang Xiang, Zhao Rui, Ford Heide L, Mukherjee Neelanjan

Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses.

源自患者的三阴性乳腺癌异种移植模型能够对化疗反应进行解卷积和预测

Lei Jonathan T, Dobrolecki Lacey E, Huang Chen, Srinivasan Ramakrishnan R, Vasaikar Suhas V, Lewis Alaina N, Sallas Christina, Zhao Na, Cao Jin, Landua John D, Moon Chang In, Liao Yuxing, Hilsenbeck Susan G, Osborne C Kent, Rimawi Mothaffar F, Ellis Matthew J, Petrosyan Varduhi, Wen Bo, Li Kai, Saltzman Alexander B, Jain Antrix, Malovannaya Anna, Wulf Gerburg M, Marangoni Elisabetta, Li Shunqiang, Kraushaar Daniel C, Wang Tao, Damodaran Senthil, Zheng Xiaofeng, Meric-Bernstam Funda, Echeverria Gloria V, Anurag Meenakshi, Chen Xi, Welm Bryan E, Welm Alana L, Zhang Bing, Lewis Michael T

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

一个包含基因组和病理注释的泛癌患者来源异种移植组织学图像库可实现深度学习分析

White, Brian S; Woo, Xing Yi; Koc, Soner; Sheridan, Todd; Neuhauser, Steven B; Wang, Shidan; Evrard, Yvonne A; Chen, Li; Foroughi Pour, Ali; Landua, John D; Mashl, R Jay; Davies, Sherri R; Fang, Bingliang; Raso, Maria Gabriela; Evans, Kurt W; Bailey, Matthew H; Chen, Yeqing; Xiao, Min; Rubinstein, Jill C; Sanderson, Brian J; Lloyd, Michael W; Domanskyi, Sergii; Dobrolecki, Lacey E; Fujita, Maihi; Fujimoto, Junya; Xiao, Guanghua; Fields, Ryan C; Mudd, Jacqueline L; Xu, Xiaowei; Hollingshead, Melinda G; Jiwani, Shahanawaz; Acevedo, Saul; Davis-Dusenbery, Brandi N; Robinson, Peter N; Moscow, Jeffrey A; Doroshow, James H; Mitsiades, Nicholas; Kaochar, Salma; Pan, Chong-Xian; Carvajal-Carmona, Luis G; Welm, Alana L; Welm, Bryan E; Govindan, Ramaswamy; Li, Shunqiang; Davies, Michael A; Roth, Jack A; Meric-Bernstam, Funda; Xie, Yang; Herlyn, Meenhard; Ding, Li; Lewis, Michael T; Bult, Carol J; Dean, Dennis A 2nd; Chuang, Jeffrey H

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool

抗原呈递保障造血干细胞库的完整性

Pablo Hernández-Malmierca ,Dominik Vonficht ,Alexandra Schnell ,Hannah J Uckelmann ,Alina Bollhagen ,Mohamed A A Mahmoud ,Sophie-Luise Landua ,Elise van der Salm ,Christine L Trautmann ,Simon Raffel ,Florian Grünschläger ,Raphael Lutz ,Michael Ghosh ,Simon Renders ,Nádia Correia ,Elisa Donato ,Karin O Dixon ,Christoph Hirche ,Carolin Andresen ,Claudia Robens ,Paula S Werner ,Tobias Boch ,David Eisel ,Wolfram Osen ,Franziska Pilz ,Adriana Przybylla ,Corinna Klein ,Frank Buchholz ,Michael D Milsom ,Marieke A G Essers ,Stefan B Eichmüller ,Wolf-Karsten Hofmann ,Daniel Nowak ,Daniel Hübschmann ,Michael Hundemer ,Christian Thiede ,Lars Bullinger ,Carsten Müller-Tidow ,Scott A Armstrong ,Andreas Trumpp ,Vijay K Kuchroo ,Simon Haas

Internal Standard Triggered-Parallel Reaction Monitoring Mass Spectrometry Enables Multiplexed Quantification of Candidate Biomarkers in Plasma

内部标准触发平行反应监测质谱法可实现血浆中候选生物标志物的多重定量

Jacob J Kennedy, Jeffrey R Whiteaker, Richard G Ivey, Aura Burian, Shrabanti Chowdhury, Chia-Feng Tsai, Tao Liu, ChenWei Lin, Oscar D Murillo, Rachel A Lundeen, Lisa A Jones, Philip R Gafken, Gary Longton, Karin D Rodland, Steven J Skates, John Landua, Pei Wang, Michael T Lewis, Amanda G Paulovich