日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Membrane Permeability Drives the Extreme Potency of Fentanyl

膜通透性是芬太尼极强效力的驱动因素。

期刊:JACS Au
影响因子:8.7
doi:10.1021/jacsau.5c01666
Clayton, Joseph; Farmer, George J; Glenn, Jacqueline; Mistry, Shailesh N; Lane, J Robert; Shi, Lei; Stavitskaya, Lidiya; Canals, Meritxell; Shen, Jana
发表日期：2026
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Design, Synthesis, and Characterization of Novel, Subtype-Selective Fluorescent Antagonists Targeting the Nociceptin/Orphanin FQ Opioid Peptide Receptor

新型亚型选择性荧光拮抗剂的设计、合成和表征，该拮抗剂靶向伤害感受素/孤啡肽FQ阿片肽受体

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02707
Farmer, George J; Sanchez, Julie; Millns, Annabell; Antony, Tamzin; Canals, Meritxell; Lane, J Robert; Mistry, Shailesh N
信号转导
IF
发表日期：2026
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Tailoring cariprazine for dual disorders via secondary pharmacophore optimization

通过二级药效团优化来定制卡利拉嗪用于治疗双重疾病

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2026.118654
Vogt, Caleb D; Sanchez, Julie; Bonifazi, Alessandro; Saab, Elizabeth; Ranjit, Arina; Rais, Rana; Lane, J Robert; Newman, Amy Hauck
发表日期：2026
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Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D(3) Dopamine Receptor.

发现、表征和优化一种新型的D(3)多巴胺受体正向变构调节剂-拮抗剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01585
Moritz Amy E, Wang Feijun, Madaras Nora S, Kelley Amber M, Snyder Kirsten K, Gandhi Disha, Inbody Laura R, Akano Emmanuel O, Shi Lei, Lane J Robert, Free R Benjamin, Frankowski Kevin J, Sibley David R
其它
发表日期：2025
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Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D(2) Receptor.

鉴定多巴胺 D(2) 受体正变构调节剂的脂质暴露螺旋外结合位点

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00105
Lim Herman D, Bartuzi Damian, Keen Alastair C, Rauffenbart Caroline, Glenn Jacqueline, Charlton Steven J, Lovera Silvia, Sands Zara A, Ates Ali, Wood Martyn, Canals Meritxell, Javitch Jonathan A, Carlsson Jens, Lane J Robert
信号转导
发表日期：2025
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Membrane Permeability Drives the Extreme Potency of Fentanyl but not Isotonitazene

膜通透性是芬太尼而非异硝尼嗪发挥极强效力的驱动因素。

期刊:
影响因子:
doi:10.1101/2025.07.22.666146
Clayton, Joseph; Farmer, George J; Glenn, Jacqueline; Mistry, Shailesh N; Lane, J Robert; Shi, Lei; Stavitskaya, Lidiya; Canals, Meritxell; Shen, Jana
发表日期：2025
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Assessment of the potential of novel and classical opioids to induce respiratory depression in mice

评估新型和经典阿片类药物诱导小鼠呼吸抑制的潜力

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1111/bph.16199
Hill, Rob; Sanchez, Julie; Lemel, Laura; Antonijevic, Mirjana; Hosking, Yselkla; Mistry, Shailesh N; Kruegel, Andrew C; Javitch, Jonathan A; Lane, J Robert; Canals, Meritxell
发表日期：2023
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The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine

帽柱木碱的呼吸抑制作用受限于其向7-羟基帽柱木碱的转化。

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1111/bph.15832
Hill, Rob; Kruegel, Andrew C; Javitch, Jonathan A; Lane, J Robert; Canals, Meritxell
发表日期：2022
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The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface

氯氮平和其他抗精神病药物对多巴胺D2受体向细胞表面转位的不同作用

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.RA118.004682
Schrader, Joseph M; Irving, Craig M; Octeau, J Christopher; Christian, Joseph A; Aballo, Timothy J; Kareemo, Dean J; Conti, Joseph; Camberg, Jodi L; Lane, J Robert; Javitch, Jonathan A; Kovoor, Abraham
信号转导
细胞生物学
发表日期：2019
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Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites

鉴定作用于不同结合位点的D(1)多巴胺受体正向变构调节剂

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/mol.118.113175
Luderman, Kathryn D; Conroy, Jennie L; Free, R Benjamin; Southall, Noel; Ferrer, Marc; Sanchez-Soto, Marta; Moritz, Amy E; Willette, Blair K A; Fyfe, Tim J; Jain, Prashi; Titus, Steve; Hazelwood, Lisa A; Aubé, Jeffrey; Lane, J Robert; Frankowski, Kevin J; Sibley, David R
信号转导
发表日期：2018
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