日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis.

溶酶体蛋白酶介导的 APP 降解是 pH 依赖性的、对突变敏感的,并且促进 tau 蛋白水解。

Ackley Caroline, Liau Zoe, Arya Shruti, Antee Tara, Cheang Emily, Knudsen Giselle M, Lane-Donovan Courtney, Sampognaro Paul J, Kao Aimee W

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

阿尔茨海默病生物标志物位点的 Tau 蛋白磷酸化会损害溶酶体蛋白酶对其的切割

Lane-Donovan Courtney, Smith Andrew W, Saloner Rowan, Miller Bruce L, Casaletto Kaitlin B, Kao Aimee W

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases

溶酶体和蛋白质稳态应激在儿童神经系统疾病和成人神经退行性疾病交叉领域中的作用

Lane-Donovan, Courtney; Paredes, Mercedes; Kao, Aimee W

Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease

接受 Lecanemab 治疗的阿尔茨海默病患者脑海绵状血管畸形的变化

Schwartz, Nicholas U; Dietz, Connor D; Prufer Araújo, Igor; Villanueva-Meyer, Javier E; Chiong, Winston; Lane-Donovan, Courtney; Vandevrede, Lawren; Ljubenkov, Peter A; Wang, Yingbing; Soleimani-Meigooni, David N; La Joie, Renaud; Rojas, Julio C

Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau Proteolysis.

溶酶体蛋白酶介导的 APP 降解依赖于 pH 值,对突变敏感,并促进 Tau 蛋白水解

Ackley Caroline, Liau Zoe, Arya Shruti, Antee Tara, Knudsen Giselle M, Lane-Donovan Courtney, Sampognaro Paul J, Kao Aimee W

Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias

探讨头部外伤类型和程度与老年阿尔茨海默病及相关痴呆症患者透明隔腔的关系

Asken, Breton M; Tanner, Jeremy A; Vandevrede, Lawren; Apple, Alexandra; Chapleau, Marianne; Gaynor, Leslie S; Lane-Donovan, Courtney; Lenio, Steven; Yadollahikhales, Golnaz; Lee, Shannon; Gontrum, Eva; Knudtson, Marguerite; Iaccarino, Leonardo; La Joie, Renaud; Cobigo, Yann; Staffaroni, Adam M; Casaletto, Kaitlin B; Gardner, Raquel C; Grinberg, Lea T; Gorno-Tempini, Maria Luisa; Rosen, Howard J; Seeley, William W; Miller, Bruce L; Kramer, Joel; Rabinovici, Gil D

Disentangling tau: One protein, many therapeutic approaches

解开tau蛋白之谜:一种蛋白,多种治疗方法

Lane-Donovan, Courtney; Boxer, Adam L

Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues

神经退行性疾病中的Tau蛋白病理:疾病机制和治疗途径

Samudra, Niyatee; Lane-Donovan, Courtney; VandeVrede, Lawren; Boxer, Adam L

Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner

Reelin 通过纹状体富集蛋白酪氨酸磷酸酶 (STEP61) 和钙通透性 AMPAR 以 NMDAR 依赖的方式调节神经元兴奋性

Murat S Durakoglugil, Catherine R Wasser, Connie H Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease

逆转 ApoE4 诱导的循环阻断是预防阿尔茨海默病的新方法

Xunde Xian #, Theresa Pohlkamp #, Murat S Durakoglugil, Connie H Wong, Jürgen K Beck, Courtney Lane-Donovan, Florian Plattner, Joachim Herz