日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In vivo screening reveals cell-intrinsic mediators of solid tumor resistance to CAR T cell-therapy

体内筛选揭示了实体瘤对CAR-T细胞疗法产生耐药性的细胞内在介质

Fröse, Julia; Whittaker, Charles A; Leclerc, Paul; Chen, Evelyn; Doherty, Sean; Langenbucher, Adam; Hellinger, Riley D; Goulet, Daniel; Tammela, Tuomas; Hemann, Michael T

Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma.

整合单细胞生物物理和转录组特征以解析套细胞淋巴瘤的功能异质性

Zhang Ye, Debaize Lydie, Langenbucher Adam, Weekes Jenalyn, Vogiatzi Ioulia, Miettinen Teemu P, Zhang Mingzeng, Sumpena Emily, Liu Huiyun, Duquette Sarah M, Hackett Liam, Zhang Jeremy, Baghiyan Sona, Redd Robert A, Aryee Martin, Davids Matthew S, Kim Austin I, Ryan Christine E, Weinstock David M, Manalis Scott R, Murakami Mark A

An extended APOBEC3A mutation signature in cancer

癌症中扩展的 APOBEC3A 突变特征

Langenbucher, Adam; Bowen, Danae; Sakhtemani, Ramin; Bournique, Elodie; Wise, Jillian F; Zou, Lee; Bhagwat, Ashok S; Buisson, Rémi; Lawrence, Michael S

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer

ROS1 融合阳性肺癌对克唑替尼和劳拉替尼的耐药机制

Jessica J Lin #, Noura J Choudhury #, Satoshi Yoda #, Viola W Zhu, Ted W Johnson, Ramin Sakhtemani, Ibiayi Dagogo-Jack, Subba R Digumarthy, Charlotte Lee, Andrew Do, Jennifer Peterson, Kylie Prutisto-Chang, Wafa Malik, Harper G Hubbeling, Adam Langenbucher, Adam J Schoenfeld, Christina J Falcon, Jen

APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma

在HPV阳性头颈部鳞状细胞癌中,肿瘤基因组和病毒基因组的APOBEC突变具有一致性

Faden, Daniel L; Kuhs, Krystle A Lang; Lin, Maoxuan; Langenbucher, Adam; Pinheiro, Maisa; Yeager, Meredith; Cullen, Michael; Boland, Joseph F; Steinberg, Mia; Bass, Sara; Lewis, James S; Lawrence, Michael S; Ferris, Robert L; Mirabello, Lisa

HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures

来自患有两处肿瘤的HPV阳性口咽鳞状细胞癌患者的肿瘤显示出病毒基因组的同步性,但突变谱和特征却不一致。

Faden, Daniel L; Langenbucher, Adam; Kuhs, Krystle; Lewis, James S; Mirabello, Lisa; Yeager, Meredith; Boland, Joseph F; Bass, Sara; Steinberg, Mia; Cullen, Michael; Lawrence, Michael S; Ferris, Robert L

MET Alterations Are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer

MET改变是ALK阳性肺癌中一种反复出现且可靶向治疗的耐药机制

Dagogo-Jack, Ibiayi; Yoda, Satoshi; Lennerz, Jochen K; Langenbucher, Adam; Lin, Jessica J; Rooney, Marguerite M; Prutisto-Chang, Kylie; Oh, Audris; Adams, Nathaniel A; Yeap, Beow Y; Chin, Emily; Do, Andrew; Marble, Hetal D; Stevens, Sara E; Digumarthy, Subba R; Saxena, Ashish; Nagy, Rebecca J; Benes, Cyril H; Azzoli, Christopher G; Lawrence, Michael S; Gainor, Justin F; Shaw, Alice T; Hata, Aaron N

Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition

对 ROS1 抑制剂耐药的 ROS1 融合阳性肺癌的小细胞转化

Lin, Jessica J; Langenbucher, Adam; Gupta, Pranav; Yoda, Satoshi; Fetter, Isobel J; Rooney, Marguerite; Do, Andrew; Kem, Marina; Chang, Kylie Prutisto; Oh, Audris Y; Chin, Emily; Juric, Dejan; Corcoran, Ryan B; Dagogo-Jack, Ibiayi; Gainor, Justin F; Stone, James R; Lennerz, Jochen K; Lawrence, Michael S; Hata, Aaron N; Mino-Kenudson, Mari; Shaw, Alice T

Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.

APOBEC3A 和中尺度基因组特征驱动的癌症中的乘客热点突变

Buisson Rémi, Langenbucher Adam, Bowen Danae, Kwan Eugene E, Benes Cyril H, Zou Lee, Lawrence Michael S