日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation.

LYMTACs:嵌合小分子可重新利用溶酶体膜蛋白,实现靶蛋白的重新定位和降解

Nalawansha Dhanusha A, Mazis Georgios, Husemoen Gitte, Ashton Kate S, Deng Weixian, Wurz Ryan P, Tran Anh T, Lanman Brian A, Xie Jiansong, Guenette Robert G, Li Shiqian, Smith Christopher E, Archunan Suresh, Agnihotram Manoj K, Sadhukhan Arghya, Kapoor Rajiv, Wilde Chris, Koirala Sajjan, De Sousa E Melo Felipe, Potts Patrick Ryan

Identification of Structurally Novel KRAS(G12C) Inhibitors through Covalent DNA-Encoded Library Screening

通过共价DNA编码文库筛选鉴定结构新颖的KRAS(G12C)抑制剂

Huang, David; Manoni, Francesco; Sun, Zhen; Liu, Rongfeng; Allen, Jennifer R; Banerjee, Abhisek; Cee, Victor J; Eshon, Josephine; Frohn, Michael J; Kaller, Matthew R; Lee, Heejun; Li, Cui; Li, Xun; Lopez, Patricia; Ma, Vu; Medina, Jose M; Mohr, Christopher; Mukhina, Olga A; Pickrell, Alexander J; Stellwagen, John; Wu, Wenting; Zhang, Wenhan; Zhu, Kai; Dahal, Upendra P; Hu, Liaoyuan A; Leavitt, Monica; Li, Wencui; Li, Yu; Ma, Yingli; Rex, Karen; Saiki, Anne Y; Wang, Paul; Sun, Yaping; Dai, Dongcheng; Tamayo, Nuria A; Lanman, Brian A

Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations

解决 KRAS G12C 共价抑制剂 Sotorasib 开发中的阻转异构现象:结构、分析和合成方面的考虑

Lanman, Brian A; Parsons, Andrew T; Zech, Stephan G

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors

发现和优化大环喹喔啉-吡咯并二氢哌啶酮类化合物作为强效Pim-1/2激酶抑制剂

Cee, Victor J; Chavez, Frank Jr; Herberich, Bradley; Lanman, Brian A; Pettus, Liping H; Reed, Anthony B; Wu, Bin; Wurz, Ryan P; Andrews, Kristin L; Chen, Jie; Hickman, Dean; Laszlo, Jimmy 3rd; Lee, Matthew R; Guerrero, Nadia; Mattson, Bethany K; Nguyen, Yen; Mohr, Christopher; Rex, Karen; Sastri, Christine E; Wang, Paul; Wu, Qiong; Wu, Tian; Xu, Yang; Zhou, Yihong; Winston, Jeffrey T; Lipford, J Russell; Tasker, Andrew S; Wang, Hui-Ling

Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)

发现一种强效的、不依赖S1P3的苯并噻唑类鞘氨醇-1-磷酸受体1 (S1P1) 激动剂

Lanman, Brian A; Cee, Victor J; Cheruku, Srinivasa R; Frohn, Mike; Golden, Jennifer; Lin, Jian; Lobera, Mercedes; Marantz, Yael; Muller, Kristine M; Neira, Susana C; Pickrell, Alexander J; Rivenzon-Segal, Dalia; Schutz, Nili; Sharadendu, Anurag; Yu, Xiang; Zhang, Zhaoda; Buys, Janet; Fiorino, Mike; Gore, Anu; Horner, Michelle; Itano, Andrea; McElvain, Michele; Middleton, Scot; Schrag, Michael; Vargas, Hugo M; Xu, Han; Xu, Yang; Zhang, Xuxia; Siu, Jerry; Bürli, Roland W

EVALUATION OF STRATEGIES FOR THE SYNTHESIS OF THE GUANIDINE HEMIAMINAL PORTION OF PALAU'AMINE

帕劳胺胍半氨基部分合成策略的评估

Lanman, Brian A; Overman, Larry E