日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma

靶向 ROR1 的抗体药物偶联物 VLS-101 对 CAR-T 耐药的套细胞淋巴瘤有效。

Jiang, Vivian Changying; Liu, Yang; Jordan, Alexa; McIntosh, Joseph; Li, Yijing; Che, Yuxuan; Jessen, Katti A; Lannutti, Brian J; Wang, Michael

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models

使用抗体药物偶联物VLS-101靶向ROR1在里氏综合征患者来源的异种移植小鼠模型中有效。

Vaisitti, Tiziana; Arruga, Francesca; Vitale, Nicoletta; Lee, Thanh-Trang; Ko, Mira; Chadburn, Amy; Braggio, Esteban; Di Napoli, Arianna; Iannello, Andrea; Allan, John N; Miller, Langdon L; Lannutti, Brian J; Furman, Richard R; Jessen, Katti A; Deaglio, Silvia

PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature

PI3Kγ/δ 和 NOTCH1 交叉调控定义 T 细胞急性淋巴细胞白血病疾病特征的通路

Efimenko, Evgeni; Davé, Utpal P; Lebedeva, Irina V; Shen, Yao; Sanchez-Quintero, Maria J; Diolaiti, Daniel; Kung, Andrew; Lannutti, Brian J; Chen, Jianchung; Realubit, Ronald; Niatsetskaya, Zoya; Ten, Vadim; Karan, Charles; Chen, Xi; Califano, Andrea; Diacovo, Thomas G

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

阿卡替尼(ACP-196)治疗复发性慢性淋巴细胞白血病

Byrd, John C; Harrington, Bonnie; O'Brien, Susan; Jones, Jeffrey A; Schuh, Anna; Devereux, Steve; Chaves, Jorge; Wierda, William G; Awan, Farrukh T; Brown, Jennifer R; Hillmen, Peter; Stephens, Deborah M; Ghia, Paolo; Barrientos, Jacqueline C; Pagel, John M; Woyach, Jennifer; Johnson, Dave; Huang, Jane; Wang, Xiaolin; Kaptein, Allard; Lannutti, Brian J; Covey, Todd; Fardis, Maria; McGreivy, Jesse; Hamdy, Ahmed; Rothbaum, Wayne; Izumi, Raquel; Diacovo, Thomas G; Johnson, Amy J; Furman, Richard R

A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor.

将 Idelalisib 与新型脾酪氨酸激酶 (Syk) 抑制剂 GS-9973 联合使用,有望成为治疗慢性淋巴细胞白血病的潜在疗法

Burke Russell T, Meadows Sarah, Loriaux Marc M, Currie Kevin S, Mitchell Scott A, Maciejewski Patricia, Clarke Astrid S, Dipaolo Julie A, Druker Brian J, Lannutti Brian J, Spurgeon Stephen E

The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways

磷脂酰肌醇3-激酶(PI3K)抑制剂GS-1101通过抑制PI3K和细胞外信号调节激酶通路,协同增强组蛋白去乙酰化酶抑制剂诱导的增殖抑制和细胞凋亡。

Bodo, Juraj; Zhao, Xiaoxian; Sharma, Arishya; Hill, Brian T; Portell, Craig A; Lannutti, Brian J; Almasan, Alexandru; Hsi, Eric D

Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity

PI3K p110δ 的特异性抑制可抑制 CSF-1 诱导的巨噬细胞扩散和侵袭能力。

Mouchemore, Kellie A; Sampaio, Natalia G; Murrey, Michael W; Stanley, E Richard; Lannutti, Brian J; Pixley, Fiona J

The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia.

磷脂酰肌醇 3'-激酶δ抑制剂CAL-101可抑制慢性淋巴细胞白血病中的B细胞受体信号传导和趋化因子网络

Hoellenriegel Julia, Meadows Sarah A, Sivina Mariela, Wierda William G, Kantarjian Hagop, Keating Michael J, Giese Neill, O'Brien Susan, Yu Albert, Miller Langdon L, Lannutti Brian J, Burger Jan A