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Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling

前沿研究：条件性Rasgrp1缺陷小鼠外周CD4+ T细胞中Rasgrp1的诱导性缺失揭示了Rasgrp1在TCR/CD28诱导的Ras-MAPK信号通路中的关键作用

期刊:Journal of Immunology

影响因子:3.4

doi:10.4049/jimmunol.2300138

Chang, Yating; Manivannan, Praveen; Doosti, Abbas; Lapinski, Philip E; Chen, Di; Roose, Jeroen P; King, Philip D

RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development

RASA1依赖的IV型胶原蛋白细胞输出调控血液和淋巴管发育

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI124917

Chen, Di; Teng, Joyce M; North, Paula E; Lapinski, Philip E; King, Philip D

Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation

Rasa1(R780Q)敲入小鼠的血管异常：对毛细血管畸形-动静脉畸形发病机制的启示

期刊:American Journal of Pathology

影响因子:3.6

doi:10.1016/j.ajpath.2014.08.018

Lubeck, Beth A; Lapinski, Philip E; Bauler, Timothy J; Oliver, Jennifer A; Hughes, Elizabeth D; Saunders, Thomas L; King, Philip D

发表日期：2014

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Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

Ras GTP酶激活蛋白在组织稳态中的非冗余功能

期刊:Science Signaling

影响因子:6.6

doi:10.1126/scisignal.2003669

King, Philip D; Lubeck, Beth A; Lapinski, Philip E

发表日期：2013

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Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells

早幼粒细胞白血病锌指蛋白表达的固有CD4 T细胞的发育需要比传统CD4 T细胞更强的T细胞受体信号。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1207528109

Qiao, Yu; Zhu, Lingqiao; Sofi, Hanief; Lapinski, Philip E; Horai, Reiko; Mueller, Kristen; Stritesky, Gretta L; He, Xi; Teh, Hung-Sia; Wiest, David L; Kappes, Dietmar J; King, Philip D; Hogquist, Kristin A; Schwartzberg, Pamela L; Sant'Angelo, Derek B; Chang, Cheong-Hee

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.

诱导 SHP-2 缺陷成年小鼠出现严重骨骼缺陷：SHP-2 突变人类骨骼畸形的模型

期刊:Disease Models & Mechanisms

影响因子:3.3

doi:10.1242/dmm.006130

Bauler Timothy J, Kamiya Nobuhiro, Lapinski Philip E, Langewisch Eric, Mishina Yuji, Wilkinson John E, Feng Gen-Sheng, King Philip D

MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

microRNA-132介导的p120RasGAP缺失激活内皮细胞，促进病理性血管生成

期刊:Nature Medicine

影响因子:50

doi:10.1038/nm.2186

Anand, Sudarshan; Majeti, Bharat K; Acevedo, Lisette M; Murphy, Eric A; Mukthavaram, Rajesh; Scheppke, Lea; Huang, Miller; Shields, David J; Lindquist, Jeffrey N; Lapinski, Philip E; King, Philip D; Weis, Sara M; Cheresh, David A

Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells

对SH2D4A（一种与T细胞特异性衔接蛋白和淋巴细胞中功能未知的衔接蛋白相关的新型衔接蛋白）的基因分析揭示了其在T细胞中具有冗余功能。

期刊:Journal of Immunology

影响因子:3.4

doi:10.4049/jimmunol.181.3.2019

Lapinski, Philip E; Oliver, Jennifer A; Kamen, Lynn A; Hughes, Elizabeth D; Saunders, Thomas L; King, Philip D

Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells

T细胞特异性衔接蛋白在激活外周T细胞LCK中的关键作用

期刊:Journal of Experimental Medicine

影响因子:10.6

doi:10.1084/jem.20051637

Marti, Francesc; Garcia, Gonzalo G; Lapinski, Philip E; MacGregor, Jennifer N; King, Philip D

EPHB4-RASA1 Inhibition of PIEZO1 Ras Activation Drives Lymphatic Valvulogenesis

EPHB4-RASA1抑制PIEZO1 Ras激活驱动淋巴管瓣膜形成

Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling

前沿研究：条件性Rasgrp1缺陷小鼠外周CD4+ T细胞中Rasgrp1的诱导性缺失揭示了Rasgrp1在TCR/CD28诱导的Ras-MAPK信号通路中的关键作用

RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development

RASA1依赖的IV型胶原蛋白细胞输出调控血液和淋巴管发育

Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation

Rasa1(R780Q)敲入小鼠的血管异常：对毛细血管畸形-动静脉畸形发病机制的启示

Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

Ras GTP酶激活蛋白在组织稳态中的非冗余功能

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells

早幼粒细胞白血病锌指蛋白表达的固有CD4 T细胞的发育需要比传统CD4 T细胞更强的T细胞受体信号。

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.

诱导 SHP-2 缺陷成年小鼠出现严重骨骼缺陷：SHP-2 突变人类骨骼畸形的模型

MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

microRNA-132介导的p120RasGAP缺失激活内皮细胞，促进病理性血管生成

Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells

对SH2D4A（一种与T细胞特异性衔接蛋白和淋巴细胞中功能未知的衔接蛋白相关的新型衔接蛋白）的基因分析揭示了其在T细胞中具有冗余功能。

Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells

T细胞特异性衔接蛋白在激活外周T细胞LCK中的关键作用