Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro
单链全修饰硫代磷酸酯寡核苷酸可在体外诱导结构化核内含物形成,改变核蛋白定位并扰乱转录组。
期刊:Frontiers in Genetics
影响因子:2.8
doi:10.3389/fgene.2022.791416
Flynn, Loren L; Li, Ruohan; Pitout, Ianthe L; Aung-Htut, May T; Larcher, Leon M; Cooper, Jack A L; Greer, Kane L; Hubbard, Alysia; Griffiths, Lisa; Bond, Charles S; Wilton, Steve D; Fox, Archa H; Fletcher, Sue