日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia

VIP152 是一种选择性 CDK9 抑制剂,在慢性淋巴细胞白血病中具有临床前体外和体内疗效

Steven Sher, Ethan Whipp, Janek Walker, Pu Zhang, Larry Beaver, Katie Williams, Shelley Orwick, Janani Ravikrishnan, Brandi Walker, Elizabeth Perry, Charles Gregory, Matthew Purcell, Alexander Pan, Pearlly Yan, Lapo Alinari, Amy J Johnson, Melanie M Frigault, Joy M Greer, Ahmed Hamdy, Raquel Izumi, 

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

PP2A 是一种可通过 c-Myc/p21 轴决定人类和鼠类急性髓系白血病细胞命运的治疗靶向驱动因子

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi-Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo-Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn

Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions

以 OXPHOS 从头嘌呤合成为目标,作为 FLT3 抑制剂介导的协同抗白血病作用的纽带

Pu Zhang, Lindsey T Brinton, Mehdi Gharghabi, Steven Sher, Katie Williams, Matthew Cannon, Janek S Walker, Daniel Canfield, Larry Beaver, Casey B Cempre, Hannah Phillips, Xuyong Chen, Pearlly Yan, Amy Lehman, Peggy Scherle, Min Wang, Kris Vaddi, Robert Baiocchi, Ruoning Wang, Deepa Sampath, Lapo Ali

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

复发性 XPO1 突变改变慢性淋巴细胞白血病的发病机制

Janek S Walker #, Zachary A Hing #, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N Skinner, Casey B Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R Stromberg, Matthew K Summers, Lynne V Abruzzo, Laura Rassenti, Thomas J

Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

靶向两种组蛋白去乙酰化酶 HDAC8 和 SIRT6 的 DNA 损伤修复功能,增强急性髓系白血病对 NAMPT 抑制的敏感性

Pu Zhang, Lindsey T Brinton, Katie Williams, Steven Sher, Shelley Orwick, Lai Tzung-Huei, Alice S Mims, Christopher C Coss, Samuel K Kulp, Youssef Youssef, Wing Keung Chan, Shaneice Mitchell, Allison Mustonen, Matthew Cannon, Hannah Phillips, Amy M Lehman, Tierney Kauffman, Larry Beaver, Daniel Canf

Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia

KPT-9274 在急性髓系白血病中选择性靶向 NAMPT

Shaneice R Mitchell, Karilyn Larkin, Nicole R Grieselhuber, Tzung-Huei Lai, Matthew Cannon, Shelley Orwick, Pratibha Sharma, Yerdanose Asemelash, Pu Zhang, Virginia M Goettl, Larry Beaver, Alice Mims, Vinay K Puduvalli, James S Blachly, Amy Lehman, Bonnie Harrington, Sally Henderson, Justin T Breitb

Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells

白血病 B 细胞 CTLA-4 抑制 T 细胞的共刺激

Priscilla Do, Kyle A Beckwith, Carolyn Cheney, Minh Tran, Larry Beaver, Brittany G Griffin, Xiaokui Mo, Yang Liu, Rosa Lapalombella, Erin Hertlein, Natarajan Muthusamy, John C Byrd

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

BRD4 分析可识别关键的慢性淋巴细胞白血病致癌回路并揭示对 PLX51107(一种新型结构独特的 BET 抑制剂)的敏感性

Hatice Gulcin Ozer #, Dalia El-Gamal #, Ben Powell #, Zachary A Hing, James S Blachly, Bonnie Harrington, Shaneice Mitchell, Nicole R Grieselhuber, Katie Williams, Tzung-Huei Lai, Lapo Alinari, Robert A Baiocchi, Lindsey Brinton, Elizabeth Baskin, Matthew Cannon, Larry Beaver, Virginia M Goettl, Dav