日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

SOS1 抑制剂 MRTX0902 可阻断 KRAS 激活，并在依赖 KRAS 核苷酸加载的癌症中表现出抗肿瘤活性

期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-23-0870
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Co
肿瘤
发表日期：2024
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MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

MRTX1719 是一种 MTA 协同 PRMT5 抑制剂，在 MTAP 缺失型癌症的临床前模型和患者中表现出合成致死性。

期刊:Cancer Discovery
影响因子:29.7
doi:10.1158/2159-8290.CD-23-0669
Lars D Engstrom ,Ruth Aranda ,Laura Waters ,Krystal Moya ,Vickie Bowcut ,Laura Vegar ,David Trinh ,Allan Hebbert ,Christopher R Smith ,Svitlana Kulyk ,J David Lawson ,Leo He ,Laura D Hover ,Julio Fernandez-Banet ,Jill Hallin ,Darin Vanderpool ,David M Briere ,Alice Blaj ,Matthew A Marx ,Jordi Rodon ,Michael Offin ,Kathryn C Arbour ,Melissa L Johnson ,David J Kwiatkowski ,Pasi A Jänne ,Candace L Haddox ,Kyriakos P Papadopoulos ,Jason T Henry ,Konstantinos Leventakos ,James G Christensen ,Ronald Shazer ,Peter Olson
MTAP
肿瘤
肿瘤免疫
发表日期：2023
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Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers

基于片段发现 MRTX1719，这是一种用于治疗 MTAP 缺失癌症的 PRMT5•MTA 复合物的合成致死抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c01900
Christopher R Smith, Ruth Aranda, Thomas P Bobinski, David M Briere, Aaron C Burns, James G Christensen, Jeffery Clarine, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Ronald Jean-Baptiste, John M Ketcham, Masakazu Kobayashi, Jon Kuehler, Svitlana Kulyk, J David Lawson, Krystal Moya, Peter Olson, L
肿瘤
发表日期：2022
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The KRASG12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy

KRASG12C 抑制剂 MRTX849 可重塑肿瘤免疫微环境，增强肿瘤对检查点抑制剂疗法的敏感性

期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-20-0462
David M Briere, Shuai Li, Andrew Calinisan, Niranjan Sudhakar, Ruth Aranda, Lauren Hargis, David H Peng, Jiehui Deng, Lars D Engstrom, Jill Hallin, Sole Gatto, Julio Fernandez-Banet, Adam Pavlicek, Kwok-Kin Wong, James G Christensen, Peter Olson
信号转导
肿瘤
Checkpoint
发表日期：2021
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The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

KRASG12C 抑制剂 MRTX849 为小鼠模型和患者中 KRAS 突变型癌症的治疗敏感性提供了见解

期刊:Cancer Discovery
影响因子:29.7
doi:10.1158/2159-8290.CD-19-1167
Jill Hallin, Lars D Engstrom, Lauren Hargis, Andrew Calinisan, Ruth Aranda, David M Briere, Niranjan Sudhakar, Vickie Bowcut, Brian R Baer, Joshua A Ballard, Michael R Burkard, Jay B Fell, John P Fischer, Guy P Vigers, Yaohua Xue, Sole Gatto, Julio Fernandez-Banet, Adam Pavlicek, Karen Velastagui, R
肿瘤
Mouse
发表日期：2020
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The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

I/IV类HDAC抑制剂莫西替诺司他可增强肿瘤抗原呈递，减少免疫抑制细胞类型，并增强免疫检查点抑制剂疗法的效果。

期刊:Cancer Immunology Immunotherapy
影响因子:8.1
doi:10.1007/s00262-017-2091-y
David Briere ，Niranjan Sudhakar ，David M Woods ，Jill Hallin ，Lars D Engstrom ，Ruth Aranda ，Harrah Chiang ，Andressa L Sodré ，Peter Olson ，Jeffrey S Weber ，James G Christensen
细胞生物学
免疫/内分泌
肿瘤免疫
肿瘤
发表日期：2018
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Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models

格莱沙替尼在携带 MET 外显子 14 突变的肺癌模型和患者中表现出抗肿瘤活性，并在非临床模型中克服了突变介导的对 I 型 MET 抑制剂的耐药性

期刊:Clinical Cancer Research
影响因子:10
doi:10.1158/1078-0432.CCR-17-1192
Lars D Engstrom, Ruth Aranda, Matthew Lee, Elizabeth A Tovar, Curt J Essenburg, Zachary Madaj, Harrah Chiang, David Briere, Jill Hallin, Pedro P Lopez-Casas, Natalia Baños, Camino Menendez, Manuel Hidalgo, Vanessa Tassell, Richard Chao, Darya I Chudova, Richard B Lanman, Peter Olson, Lyudmilla Bazhe
信号转导
肿瘤
肺癌
发表日期：2017
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