Lars Velten相关文献与解析，生知库 | 链接生命科学的每一步

Michael Scherer # ，Indranil Singh # ，Martina Maria Braun # ，Chelsea Szu-Tu # ，Pedro Sanchez Sanchez ，Dominik Lindenhofer ，Niels Asger Jakobsen ，Verena Körber ，Michael Kardorff ，Lena Nitsch ，Pauline Kautz ，Julia Rühle ，Agostina Bianchi ，Luca Cozzuto ，Robert Frömel ，Sergi Beneyto-Calabuig ，Caleb Lareau ，Ansuman T Satpathy ，Renée Beekman ，Lars M Steinmetz ，Simon Raffel ，Leif S Ludwig ，Paresh Vyas ，Alejo Rodriguez-Fraticelli ，Lars Velten

表观遗传

细胞生物学

衰老

发表日期：2025

文献求助收藏

Design principles of cell-state-specific enhancers in hematopoiesis

造血过程中细胞状态特异性增强子的设计原则

期刊:Cell

影响因子:45.5

doi:10.1016/j.cell.2025.04.017

Robert Frömel,Julia Rühle,Aina Bernal Martinez,Chelsea Szu-Tu,Felix Pacheco Pastor,Rosa Martinez-Corral,Lars Velten

细胞生物学

发表日期：2025

文献求助收藏

Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance

控制人类白血病干细胞和治疗耐药性的表观遗传机制

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-58370-9

Sumiko Takao ，Victor Morell ，Masahiro Uni ，Alicia Slavit ，Sophia Rha ，Shuyuan Cheng ，Laura K Schmalbrock ，Fiona C Brown ，Sergi Beneyto-Calabuig ，Richard P Koche ，Lars Velten ，Alex Kentsis

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung

单细胞分裂追踪和转录组学揭示了再生肺中的细胞类型和分化途径

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-46469-4

Leila R Martins ，Lina Sieverling ，Michelle Michelhans ，Chiara Schiller ，Cihan Erkut ，Thomas G P Grünewald ，Sergio Triana ，Stefan Fröhling ，Lars Velten ，Hanno Glimm ，Claudia Scholl

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

体细胞表观突变使得在小鼠和人类生命周期内进行原生造血的单细胞谱系追踪成为可能

期刊:

影响因子:

doi:10.1101/2024.04.01.587514

Michael Scherer, Indranil Singh, Martina Braun, Chelsea Szu-Tu, Michael Kardorff, Julia Rühle, Robert Frömel, Sergi Beneyto-Calabuig, Simon Raffel, Alejo Rodriguez-Fraticelli, Lars Velten

scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells

scTAM-seq能够对单个细胞中的DNA甲基化进行高置信度的靶向分析

期刊:Genome Biology

影响因子:10.1

doi:10.1186/s13059-022-02796-7

Agostina Bianchi # ，Michael Scherer # ，Roser Zaurin ，Kimberly Quililan ，Lars Velten # ，Renée Beekman #

Single-cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos

运动神经元的单细胞 RNA 测序确定了果蝇胚胎中突触连接的调节器

期刊:Molecular Systems Biology

影响因子:8.5

doi:10.15252/msb.202110255

Jessica Velten, Xuefan Gao, Patrick Van Nierop Y Sanchez, Katrin Domsch, Rashi Agarwal, Lena Bognar, Malte Paulsen, Lars Velten, Ingrid Lohmann

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

造血系统的单细胞蛋白质基因组参考图谱能够纯化和大规模分析精确定义的细胞状态

期刊:Nature Immunology

影响因子:27.7

doi:10.1038/s41590-021-01059-0

Sergio Triana #,Dominik Vonficht #,Lea Jopp-Saile #,Simon Raffel,Raphael Lutz,Daniel Leonce,Magdalena Antes,Pablo Hernández-Malmierca,Diana Ordoñez-Rueda,Beáta Ramasz,Tobias Boch,Johann-Christoph Jann,Daniel Nowak,Wolf-Karsten Hofmann,Carsten Müller-Tidow,Daniel Hübschmann,Theodore Alexandrov,Vladimir Benes,Andreas Trumpp,Malte Paulsen,Lars Velten,Simon Haas

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

骨髓微环境中IGF1的下降会启动造血干细胞衰老。

期刊:Cell Stem Cell

影响因子:19.8

doi:10.1016/j.stem.2021.03.017

Kira Young ，Elizabeth Eudy ，Rebecca Bell ，Matthew A Loberg ，Tim Stearns ，Devyani Sharma ，Lars Velten ，Simon Haas ，Marie-Dominique Filippi ，Jennifer J Trowbridge

Targeted Perturb-seq enables genome-scale genetic screens in single cells

靶向 Perturb-seq 可在单细胞中进行基因组规模的遗传筛选

期刊:Nature Methods

影响因子:36.1

doi:10.1038/s41592-020-0837-5

Daniel Schraivogel #, Andreas R Gschwind #, Jennifer H Milbank, Daniel R Leonce, Petra Jakob, Lukas Mathur, Jan O Korbel, Christoph A Merten, Lars Velten, Lars M Steinmetz

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

利用体细胞表观突变进行克隆追踪揭示血液衰老的动态过程

Design principles of cell-state-specific enhancers in hematopoiesis

造血过程中细胞状态特异性增强子的设计原则

Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance

控制人类白血病干细胞和治疗耐药性的表观遗传机制

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung

单细胞分裂追踪和转录组学揭示了再生肺中的细胞类型和分化途径

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

体细胞表观突变使得在小鼠和人类生命周期内进行原生造血的单细胞谱系追踪成为可能

scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells

scTAM-seq能够对单个细胞中的DNA甲基化进行高置信度的靶向分析

Single-cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos

运动神经元的单细胞 RNA 测序确定了果蝇胚胎中突触连接的调节器

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

造血系统的单细胞蛋白质基因组参考图谱能够纯化和大规模分析精确定义的细胞状态

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

骨髓微环境中IGF1的下降会启动造血干细胞衰老。

Targeted Perturb-seq enables genome-scale genetic screens in single cells

靶向 Perturb-seq 可在单细胞中进行基因组规模的遗传筛选