日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell analysis reveals neuroprotective histone deacetylase inhibitor pathways.

单细胞分析揭示了神经保护性组蛋白去乙酰化酶抑制剂通路。

Peyton Madeline, Jury-Garfe Nur, Liu Jiahui, Beimfohr Caleb, Sunil Chitra, Brooks Steven, Zhang Pengyue, McCabe Sean D, Richardson Timothy I, Huang Kun, Lasagna-Reeves Cristian A, Zhang Jie, Johnson Travis S

Tau in Alzheimer's disease: Shaping the future patient journey

阿尔茨海默病中的Tau蛋白:塑造未来患者旅程

Mummery, Catherine J; Li-Hsian, Christopher Chen; Lasagna-Reeves, Cristian A; Ossenkoppele, Rik; Rowe, Christopher C; Scharre, Douglas W; Wang, Huali; Kyaga, Simon; Cummings, Jeffrey L

Correction: The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes

更正:tau蛋白孔状结构的形成普遍存在且具有细胞特异性:可能对疾病表型产生影响

Lasagna-Reeves, Cristian A; Sengupta, Urmi; Castillo-Carranza, Diana; Gerson, Julia E; Guerrero-Munoz, Marcos; Troncoso, Juan C; Jackson, George R; Kayed, Rakez

Therapeutic Targeting of Microglial Hexokinase-2 Recalibrates Inflammasome Activation and Improves Functional Recovery After Traumatic Brain Injury

靶向小胶质细胞己糖激酶-2的治疗可重新调节炎症小体激活并改善创伤性脑损伤后的功能恢复

Mera-Reina, Claudia; Codocedo, Juan F; Fallen, Paul B; Scott, Jack; Lasagna-Reeves, Cristian A; Landreth, Gary E

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy

TREM2 缺陷导致小鼠脑淀粉样血管病模型出现区域特异性脑损伤

Wang, Yiqin; Wen, Qiong; Jin, Luhua; Chen, Wei; Mercado, Constanza; Amaro, Armando; Martinez-Pinto, Jonathan; Vidal, Ruben; Jury-Garfe, Nur; Lasagna-Reeves, Cristian A

Spatially resolved transcriptomic profiling identifies distinct signatures in parenchymal and vascular microenvironments in Alzheimer's Disease with Cerebral Amyloid Angiopathy

空间分辨转录组分析揭示了阿尔茨海默病伴脑淀粉样血管病中实质和血管微环境的独特特征

Chimal-Juárez, Enrique; Jury-Garfe, Nur; Gomez-Isaza, Laura; Troncoso, Juan C; Lasagna-Reeves, Cristian A

Tau depletion diminishes vascular amyloid-related deficits in a mouse model of cerebral amyloid angiopathy.

在脑淀粉样血管病小鼠模型中,Tau蛋白的减少可减轻血管淀粉样蛋白相关的缺陷

Jury-Garfe Nur, Chimal-Juárez Enrique, Patel Henika, Martinez-Pinto Jonathan, Vanderbosch Kathryn, Mardones Muriel D, Perkins Abigail, Prisco Gonzalo Viana Di, Marambio Yamil, Vidal Ruben, Atwood Brady K, Lasagna-Reeves Cristian A

Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation.

在两种 tau 蛋白病小鼠模型中,丝氨酸 214 的磷酸化与 tau 蛋白的播种活性呈年龄依赖性相关,并且是 tau 蛋白跨突触传播所必需的。

Martinez Pablo, Jury-Garfe Nur, Patel Henika, You Yanwen, Perkins Abigail, You Yingjian, Lee-Gosselin Audrey, Vidal Ruben, Lasagna-Reeves Cristian A

Tau-seed interactome analysis reveals distinct functional signatures in Alzheimer's disease across model systems.

Tau 种子相互作用组分析揭示了阿尔茨海默病在不同模型系统中的独特功能特征

Martinez Pablo, Patel Henika, You Yanwen, Lopes Daniella, Amaro Armando, Jury-Garfe Nur, Min Yuhao, Redding-Ochoa Javier, Dutta Sayan, Rochet Jean-Christophe, Ertekin-Taner Nilüfer, Troncoso Juan C, Lasagna-Reeves Cristian A

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model

TYK2 在 tau 蛋白病小鼠模型中调节 tau 蛋白水平、磷酸化和聚集。

Jiyoen Kim ,Bakhos Tadros ,Yan Hong Liang ,Youngdoo Kim ,Cristian Lasagna-Reeves ,Jun Young Sonn ,Dah-Eun Chloe Chung ,Bradley Hyman ,David M Holtzman ,Huda Yahya Zoghbi