日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs

应用人源化小鼠模型模拟细胞色素P450介导的药物代谢,预测肽类药物与小分子药物之间的药物相互作用

Kapelyukh, Yury; Gabel-Jensen, Charlotte; MacLeod, Alastaire Kenneth; Daniel Coquelin, Kevin-Sebastien; Stojanovski, Laste; Frame, Laura; Tavendale, Amy; Henderson, Colin J; Read, Kevin D; Wolf, Charles Roland; Säll, Carolina

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues

2,4-二氨基噻唑系列药物的开发用于治疗非洲人类锥虫病,凸显了类似物静态杀灭筛选的重要性

Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, Iain T Collie, Irene Hallyburton, Robert Kime, Frederick R C Simeons, Laste Stojanovski

Graft-versus-host disease and other cutaneous manifestations in pediatric patients transplanted for Fanconi anemia

接受范可尼贫血症移植的儿科患者的移植物抗宿主病和其他皮肤表现

Laste, Leane Dhara Dalle; Schmidt, Pâmela; Moreira, Gabriela Araujo; Silva, Janine Horsth; Abagge, Kerstin Taniguchi

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

重新定位二氨基噻唑系列化合物,证实其靶向细胞周期蛋白依赖性激酶CRK12,可用于治疗非洲动物锥虫病

Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease

鉴定和开发一系列二取代哌嗪类化合物用于治疗恰加斯病

McGonagle, Kate; Tarver, Gary J; Cantizani, Juan; Cotillo, Ignacio; Dodd, Peter G; Ferguson, Liam; Gilbert, Ian H; Marco, Maria; Miles, Tim; Naylor, Claire; Osuna-Cabello, Maria; Paterson, Christy; Read, Kevin D; Pinto, Erika G; Riley, Jennifer; Scullion, Paul; Shishikura, Yoko; Simeons, Frederick; Stojanovski, Laste; Svensen, Nina; Thomas, John; Wyatt, Paul G; Manzano, Pilar; De Rycker, Manu; Thomas, Michael G

Dilated cardiomyopathy in cats: survey of veterinary cardiologists and retrospective evaluation of a possible association with diet

猫扩张型心肌病:兽医心脏病专家调查及与饮食可能相关的回顾性评估

Karp, S I; Freeman, L M; Rush, J E; Arsenault, W G; Cunningham, S M; DeFrancesco, T C; Karlin, E T; Laste, N J; Lefbom, B K; Plante, C; Rodriguez, K T; Tyrrell, W D; Yang, V K

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

基于一系列蛋白酶体抑制剂的支架跃迁策略,我们获得了一种用于治疗内脏利什曼病的临床前候选药物。

Thomas, Michael; Brand, Stephen; De Rycker, Manu; Zuccotto, Fabio; Lukac, Iva; Dodd, Peter G; Ko, Eun-Jung; Manthri, Sujatha; McGonagle, Kate; Osuna-Cabello, Maria; Riley, Jennifer; Pont, Caterina; Simeons, Frederick; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Viayna, Elisabet; Fiandor, Jose M; Martin, Julio; Wyatt, Paul G; Miles, Timothy J; Read, Kevin D; Marco, Maria; Gilbert, Ian H

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

N-肉豆蔻酰转移酶作为杜氏利什曼原虫药物靶点的药理学验证

Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J Wall, Leah S Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski, Sujatha Manthri, Irene Hallyburton, Fabio Zuccotto, Paul G Wyatt, Manu De Rycker, David Horn, Michael A J Ferguson, Joachim Clos, Kevin D Read,

Optimization of Ralstonia solanacearum cell growth using a central composite rotational design for the P(3HB) production: Effect of agitation and aeration

利用中心复合旋转设计优化青枯菌细胞生长以生产P(3HB):搅拌和通气的影响

Alves, Mariane Igansi; Macagnan, Karine Laste; Piecha, Camila Rios; Torres, Matheus Marques; Perez, Izadora Almeida; Kesserlingh, Sônia Maria; Rodrigues, Rosane da Silva; de Oliveira, Patrícia Diaz; Moreira, Angelita da Silveira