日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues

2,4-二氨基噻唑系列药物的开发用于治疗非洲人类锥虫病,凸显了类似物静态杀灭筛选的重要性

Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, Iain T Collie, Irene Hallyburton, Robert Kime, Frederick R C Simeons, Laste Stojanovski

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

N-肉豆蔻酰转移酶作为杜氏利什曼原虫药物靶点的药理学验证

Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J Wall, Leah S Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski, Sujatha Manthri, Irene Hallyburton, Fabio Zuccotto, Paul G Wyatt, Manu De Rycker, David Horn, Michael A J Ferguson, Joachim Clos, Kevin D Read,

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

甲硫氨酰-tRNA 合成酶作为杜氏利什曼原虫可用药靶点的化学验证

Leah S Torrie, Stephen Brand, David A Robinson, Eun Jung Ko, Laste Stojanovski, Frederick R C Simeons, Susan Wyllie, John Thomas, Lucy Ellis, Maria Osuna-Cabello, Ola Epemolu, Andrea Nühs, Jennifer Riley, Lorna MacLean, Sujatha Manthri, Kevin D Read, Ian H Gilbert, Alan H Fairlamb, Manu De Rycker

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

PDK1 调节 B 细胞发育过程中的 VDJ 重组、细胞周期退出和存活

Ram K C Venigalla, Victoria A McGuire, Rosemary Clarke, Janet C Patterson-Kane, Ayaz Najafov, Rachel Toth, Pierre C McCarthy, Frederick Simeons, Laste Stojanovski, J Simon C Arthur

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

N-肉豆蔻酰转移酶抑制剂作为治疗昏睡病的新线索

Julie A Frearson, Stephen Brand, Stuart P McElroy, Laura A T Cleghorn, Ondrej Smid, Laste Stojanovski, Helen P Price, M Lucia S Guther, Leah S Torrie, David A Robinson, Irene Hallyburton, Chidochangu P Mpamhanga, James A Brannigan, Anthony J Wilkinson, Michael Hodgkinson, Raymond Hui, Wei Qiu, Olawa

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

鉴定出一种 κ-阿片类激动剂,作为治疗非洲人类锥虫病的强效选择性药物开发先导物

Deuan C Jones, Irene Hallyburton, Laste Stojanovski, Kevin D Read, Julie A Frearson, Alan H Fairlamb