日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis

发现莱那卡帕韦:首个用于 HIV-1 治疗和暴露前预防的每年两次给药的衣壳抑制剂

Canales, Eda; Tse, Winston; Schroeder, Scott D; Chou, Chien-Hung; Liu, Qi; Zhang, Jennifer; Lazerwith, Scott E; Morganelli, Philip; Saito, Roland D; Brizgys, Gediminas; Li, Jiayao; Wu, Qiaoyin; Graupe, Michael; Halcomb, Randall L; Desai, Manoj; Cannizzaro, Carina; Hu, Eric; Perry, Jason K; Villaseñor, Armando G; Somoza, John R; Ferrao, Ryan D; Swaminathan, S; Zheng, Jim; Lu, Bing; Mwangi, Judy; Wang, Kelly; Subramanian, Raju; Smith, Bill J; Rhodes, Gerry; Rowe, William; Sauer, Dorothea; Lad, Latesh; Papalia, Giuseppe A; Clancy, Sheila; Stepan, George J; Yu, Helen; Sakowicz, Roman; Shi, Bing; Carr, Gavin; Bam, Rujuta A; Tsai, Luong K; Singer, Eric; Hansen, Derek; Mulato, Andrew; Yant, Stephen R; Cihlar, Tomas; Link, John O

Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors

口服PD-L1抑制剂GS-4224选择性地与PD-L1高表达细胞结合,并在晚期实体瘤患者中引发药效学反应。

Odegard, Jared M; Othman, Ahmed A; Lin, Kai-Wen; Wang, Adele Y; Nazareno, Jonathan; Yoon, Oh Kyu; Ling, John; Lad, Latesh; Dunbar, P Rod; Thai, Dung; Ang, Edmond; Waldron, Nicholas; Deva, Sanjeev

Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro

慢性乙型肝炎中CD8 T细胞表型分析预测HBV特异性CD8 T细胞体外功能恢复的敏感性

Rossi, Marzia; Vecchi, Andrea; Tiezzi, Camilla; Barili, Valeria; Fisicaro, Paola; Penna, Amalia; Montali, Ilaria; Daffis, Stephane; Fletcher, Simon P; Gaggar, Anuj; Medley, Jonathan; Graupe, Michael; Lad, Latesh; Loglio, Alessandro; Soffredini, Roberta; Borghi, Marta; Pollicino, Teresa; Musolino, Cristina; Alfieri, Arianna; Brillo, Federica; Laccabue, Diletta; Massari, Marco; Boarini, Chiara; Abbati, Gianluca; Pedrazzi, Giuseppe; Missale, Gabriele; Lampertico, Pietro; Ferrari, Carlo; Boni, Carolina

Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle

小分子诱导二聚化对程序性死亡配体 1 蛋白生命周期的影响

Ilean Chai #, Dmytro Kornyeyev #, Edward Hsieh, Gesham Magombedze, Lance Stapleton, Magdeleine Hung, Hyock Joo Kwon, Erin Stefanutti, JeanPhilippe Belzile, Gregg Czerwieniec, Adele Y Wang, Mariya Morar, Latesh Lad

Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide

蛋白质足迹和 X 射线晶体学揭示 PD-L1 与大环肽的相互作用

Ben Niu, Todd C Appleby, Ruth Wang, Mariya Morar, Johannes Voight, Armando G Villaseñor, Sheila Clancy, Sarah Wise, Jean-Philippe Belzile, Giuseppe Papalia, Melanie Wong, Katherine M Brendza, Latesh Lad, Michael L Gross

Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ

艾德拉利西布与磷酸肌醇 3-激酶 δ 结合的结构、生化和生物物理表征

John R Somoza, David Koditek, Armando G Villaseñor, Nikolai Novikov, Melanie H Wong, Albert Liclican, Weimei Xing, Leanna Lagpacan, Ruth Wang, Brian E Schultz, Giuseppe A Papalia, Dharmaraj Samuel, Latesh Lad, Mary E McGrath

Mechanism of inhibition of human KSP by ispinesib

ispinesib 抑制人类 KSP 的机制

Latesh Lad, Lusong Luo, Jeffrey D Carson, Kenneth W Wood, James J Hartman, Robert A Copeland, Roman Sakowicz