日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration

P2Y12 受体拮抗剂替格瑞洛可降低 ABCA4-/- 视网膜变性小鼠模型中视网膜色素上皮细胞的溶酶体 pH 值和自发荧光

期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2018.00242
Wennan Lu, Néstor M Gómez, Jason C Lim, Sonia Guha, Ann O'Brien-Jenkins, Erin E Coffey, Keith E Campagno, Stuart A McCaughey, Alan M Laties, Leif G Carlsson, Claire H Mitchell
细胞生物学
上皮细胞
Mouse
发表日期：2018
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The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes

P2X7 受体将机械应变与神经元和星形胶质细胞中的细胞因子 IL-6 上调和释放联系起来

期刊:Journal of Neurochemistry
影响因子:4.2
doi:10.1111/jnc.13998
Wennan Lu, Farraj Albalawi, Jonathan M Beckel, Jason C Lim, Alan M Laties, Claire H Mitchell
神经
胶质细胞
发表日期：2017
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Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain

通过 Pannexin 通道机械敏感地释放 5'-三磷酸腺苷以及视神经头部星形胶质细胞中 Pannexin 通道机械敏感地上调：嘌呤能参与慢性劳损的机制

期刊:Glia
影响因子:5.4
doi:10.1002/glia.22695
Jonathan M Beckel, Arthur J Argall, Jason C Lim, Jingsheng Xia, Wennan Lu, Erin E Coffey, Edward J Macarak, Mohammed Shahidullah, Nicholas A Delamere, Gulab S Zode, Val C Sheffield, Valery I Shestopalov, Alan M Laties, Claire H Mitchell
神经
胶质细胞
发表日期：2014
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Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP

患有阿尔茨海默病相关早老素 1 A246E 突变的人类成纤维细胞中的溶酶体碱化和功能障碍可以通过 cAMP 逆转

期刊:Neuroscience
影响因子:2.9
doi:10.1016/j.neuroscience.2014.01.001
E E Coffey, J M Beckel, A M Laties, C H Mitchell
信号转导
神经
阿尔茨海默症
成纤维细胞
GPCR/Calcium/cAMP
Human
发表日期：2014
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Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations

检测新鲜和培养的RPE细胞中溶酶体碱化和降解受损的方法：视网膜变性中的作用证据

期刊:Experimental Eye Research
影响因子:2.7
doi:10.1016/j.exer.2014.05.013
Guha, Sonia; Coffey, Erin E; Lu, Wennan; Lim, Jason C; Beckel, Jonathan M; Laties, Alan M; Boesze-Battaglia, Kathleen; Mitchell, Claire H
细胞生物学
发表日期：2014
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Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells

修复受损的溶酶体可增强感光细胞外节的降解，并减少视网膜色素上皮细胞中脂褐素样自发荧光。

期刊:Advances in Experimental Medicine and Biology
影响因子:
doi:10.1007/978-1-4614-3209-8_14
Guha, Sonia; Liu, Ji; Baltazar, Gabe; Laties, Alan M; Mitchell, Claire H
上皮细胞
细胞生物学
IF
发表日期：2014
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Correction: Alcohol ADME in Primates Studied with Positron Emission Tomography

更正：利用正电子发射断层扫描研究灵长类动物的酒精 ADME

期刊:Investigative Ophthalmology & Visual Science
影响因子:4.7
doi:10.1167/iovs.14-15891
Lu, Wennan; Hu, HuiLing; Sévigny, Jean; Gabelt, B'Ann T; Kaufman, Paul L; Johnson, Elaine C; Morrison, John C; Zode, Gulab S; Sheffield, Val C; Zhang, Xiulan; Laties, Alan M; Mitchell, Claire H; Simpson, J A; Li, Zizhong; Xu, Youwen; Warner, Don; Volkow, Nora D
Primate
发表日期：2013
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Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor

P2X7 受体激活引发溶酶体碱化、脂质氧化和吞噬体清除率降低

期刊:FASEB Journal
影响因子:4.4
doi:10.1096/fj.13-236166
Sonia Guha, Gabriel C Baltazar, Erin E Coffey, Leigh-Anne Tu, Jason C Lim, Jonathan M Beckel, Shaun Patel, Thor Eysteinsson, Wennan Lu, Ann O'Brien-Jenkins, Alan M Laties, Claire H Mitchell
信号转导
发表日期：2013
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Ocular safety of sildenafil citrate when administered chronically for pulmonary arterial hypertension: results from phase III, randomised, double masked, placebo controlled trial and open label extension

西地那非柠檬酸盐长期用于治疗肺动脉高压的眼部安全性：一项 III 期随机、双盲、安慰剂对照试验和开放标签扩展研究的结果

期刊:Bmj-British Medical Journal
影响因子:42.7
doi:10.1136/bmj.e554
Wirostko, Barbara M; Tressler, Charles; Hwang, Lie-Ju; Burgess, Gary; Laties, Alan M
肺动脉高压
心血管
发表日期：2012
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Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells

囊性纤维化跨膜传导调节因子促进视网膜色素上皮细胞中碱性溶酶体的再酸化。

期刊:American Journal of Physiology-Cell Physiology
影响因子:4.7
doi:10.1152/ajpcell.00278.2011
Liu, Ji; Lu, Wennan; Guha, Sonia; Baltazar, Gabriel C; Coffey, Erin E; Laties, Alan M; Rubenstein, Ronald C; Reenstra, William W; Mitchell, Claire H
上皮细胞
细胞生物学
发表日期：2012
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