日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escape

预先优化临床抗体,使其能够广泛中和SARS-CoV-2变异株并增强其抵抗病毒逃逸的能力

Zhu, Fangqiang; Rajan, Saravanan; Hayes, Conor F; Kwong, Ka Yin; Goncalves, Andre R; Zemla, Adam T; Lau, Edmond Y; Zhang, Yi; Cai, Yingyun; Goforth, John W; Landajuela, Mikel; Gilchuk, Pavlo; Kierny, Michael; Dippel, Andrew; Amofah, Bismark; Kaplan, Gilad; Cadevilla Peano, Vanessa; Morehouse, Christopher; Sparklin, Ben; Gopalakrishnan, Vancheswaran; Tuffy, Kevin M; Nguyen, Amy; Beloor, Jagadish; Kijak, Gustavo; Liu, Chang; Dijokaite-Guraliuc, Aiste; Mongkolsapaya, Juthathip; Screaton, Gavin R; Petersen, Brenden K; Desautels, Thomas A; Bennett, Drew; Conti, Simone; Segelke, Brent W; Arrildt, Kathryn T; Kaul, Samantha; Grzesiak, Emilia A; da Silva, Felipe Leno; Bates, Thomas W; Earnhart, Christopher G; Hopkins, Svetlana; Sundaram, Shivshankar; Esser, Mark T; Francica, Joseph R; Faissol, Daniel M

Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation

利用机器学习和高通量实验评估设计交叉反应抗原

Chesterman, Chelsy; Desautels, Thomas; Sierra, Luz-Jeannette; Arrildt, Kathryn T; Zemla, Adam; Lau, Edmond Y; Sundaram, Shivshankar; Laliberte, Jason; Chen, Lynn; Ruby, Aaron; Mednikov, Mark; Bertholet, Sylvie; Yu, Dong; Luisi, Kate; Malito, Enrico; Mallett, Corey P; Bottomley, Matthew J; van den Berg, Robert A; Faissol, Daniel

Computationally restoring the potency of a clinical antibody against Omicron

通过计算方法恢复临床抗体对奥密克戎病毒的效力

Desautels, Thomas A; Arrildt, Kathryn T; Zemla, Adam T; Lau, Edmond Y; Zhu, Fangqiang; Ricci, Dante; Cronin, Stephanie; Zost, Seth J; Binshtein, Elad; Scheaffer, Suzanne M; Dadonaite, Bernadeta; Petersen, Brenden K; Engdahl, Taylor B; Chen, Elaine; Handal, Laura S; Hall, Lynn; Goforth, John W; Vashchenko, Denis; Nguyen, Sam; Weilhammer, Dina R; Lo, Jacky Kai-Yin; Rubinfeld, Bonnee; Saada, Edwin A; Weisenberger, Tracy; Lee, Tek-Hyung; Whitener, Bradley; Case, James B; Ladd, Alexander; Silva, Mary S; Haluska, Rebecca M; Grzesiak, Emilia A; Earnhart, Christopher G; Hopkins, Svetlana; Bates, Thomas W; Thackray, Larissa B; Segelke, Brent W; Lillo, Antonietta Maria; Sundaram, Shivshankar; Bloom, Jesse D; Diamond, Michael S; Crowe, James E Jr; Carnahan, Robert H; Faissol, Daniel M

Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis

沙眼衣原体多态性膜蛋白家族的序列、结构预测和表位分析

Cervantes, Patrick W; Segelke, Brent W; Lau, Edmond Y; Robinson, Beverly V; Abisoye-Ogunniyan, Abisola; Pal, Sukumar; de la Maza, Luis M; Coleman, Matthew A; D'haeseleer, Patrik

Countermeasures for Preventing and Treating Opioid Overdose

预防和治疗阿片类药物过量的对策

France, Charles P; Ahern, Gerard P; Averick, Saadyah; Disney, Alex; Enright, Heather A; Esmaeli-Azad, Babak; Federico, Arianna; Gerak, Lisa R; Husbands, Stephen M; Kolber, Benedict; Lau, Edmond Y; Lao, Victoria; Maguire, David R; Malfatti, Michael A; Martinez, Girardo; Mayer, Brian P; Pravetoni, Marco; Sahibzada, Niaz; Skolnick, Phil; Snyder, Evan Y; Tomycz, Nestor; Valdez, Carlos A; Zapf, Jim

Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles.

小角 X 射线和中子散射表明,无细胞表达可产生形状规则的盘状纳米脂蛋白颗粒

Cleveland Thomas E 4th, He Wei, Evans Angela C, Fischer Nicholas O, Lau Edmond Y, Coleman Matthew A, Butler Paul

Shock Wave-Induced Damage of a Protein by Void Collapse

冲击波诱导的空隙坍塌对蛋白质的损伤

Lau, Edmond Y; Berkowitz, Max L; Schwegler, Eric

Quantifying interactions of a membrane protein embedded in a lipid nanodisc using fluorescence correlation spectroscopy

利用荧光相关光谱法定量分析嵌入脂质纳米盘中的膜蛋白的相互作用

Ly, Sonny; Bourguet, Feliza; Fischer, Nicholas O; Lau, Edmond Y; Coleman, Matthew A; Laurence, Ted A

A method to predict blood-brain barrier permeability of drug-like compounds using molecular dynamics simulations

利用分子动力学模拟预测类药化合物血脑屏障通透性的方法

Carpenter, Timothy S; Kirshner, Daniel A; Lau, Edmond Y; Wong, Sergio E; Nilmeier, Jerome P; Lightstone, Felice C

Comparison and analysis of zinc and cobalt-based systems as catalytic entities for the hydration of carbon dioxide

锌基和钴基体系作为二氧化碳水合反应催化剂的比较和分析

Lau, Edmond Y; Wong, Sergio E; Baker, Sarah E; Bearinger, Jane P; Koziol, Lucas; Valdez, Carlos A; Satcher, Joseph H Jr; Aines, Roger D; Lightstone, Felice C