文献库，生知库 | 链接生命科学的每一步

日期影响因子

High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

高通量筛选发现了一种新型的 Hsp70 小分子调节剂，该调节剂可选择性地增强错误折叠的神经元 NO 合酶的泛素化和降解

期刊:Molecular Pharmacology

doi:10.1016/j.molpha.2024.100008

Garcia Anthony M, Davis Amanda K, Martinez-Ramos Cristian, Morishima Yoshihiro, Lau Miranda, Xu Emily, Sunil Arya, Zhang Haoming, Alt Andrew, Lieberman Andrew P, Osawa Yoichi

发表日期：2025

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Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry

利用交联和质谱法绘制同源二聚体CYP102A1中蛋白质-蛋白质相互作用图谱

期刊:Biophysical Chemistry

影响因子:2.2

doi:10.1016/j.bpc.2021.106590

Felker, Dana; Zhang, Haoming; Bo, Zhiyuan; Lau, Miranda; Morishima, Yoshihiro; Schnell, Santiago; Osawa, Yoichi

发表日期：2021

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Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery

Hsp90α和Hsp90β在多蛋白Hsp90/Hsp70依赖性分子伴侣机制激活糖皮质激素受体中的分子伴侣活性和二聚化特性

期刊:Molecular Pharmacology

doi:10.1124/mol.118.112516

Morishima, Yoshihiro; Mehta, Ranjit K; Yoshimura, Miyako; Lau, Miranda; Southworth, Daniel R; Lawrence, Theodore S; Pratt, William B; Nyati, Mukesh K; Osawa, Yoichi

免疫/内分泌

发表日期：2018

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Plant-Derived Small Molecule Inhibitors of Neuronal NO-Synthase: Potential Effects on Protein Degradation

植物来源的小分子神经元一氧化氮合酶抑制剂：对蛋白质降解的潜在影响

期刊:Plant Signaling & Behavior

影响因子:3.6

doi:10.4161/psb.2.2.4071

Osawa, Yoichi; Lau, Miranda; Lowe, Ezra R

发表日期：2007

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Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group

神经元型一氧化氮合酶对氨基胍、二氨基胍和NG-氨基-L-精氨酸的代谢以及血红素辅基的共价修饰

期刊:Chemical Research in Toxicology

影响因子:3.8

doi:10.1021/tx050263c

Lee, Anthony J; Noon, Kathleen R; Jianmongkol, Suree; Lau, Miranda; Jenkins, Gary J; Osawa, Yoichi

发表日期：2005

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