日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer

一项针对绝经后局部晚期或转移性雌激素受体阳性乳腺癌女性患者的GDC-0927开放标签I期研究

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-23-0011
Chandarlapaty, Sarat; Dickler, Maura N; Perez Fidalgo, Jose Alejandro; Villanueva-Vázquez, Rafael; Giltnane, Jennifer; Gates, Mary; Chang, Ching-Wei; Cheeti, Sravanthi; Fredrickson, Jill; Wang, Xiaojing; Collier, Ann; Moore, Heather M; Metcalfe, Ciara; Lauchle, Jennifer; Humke, Eric W; Bardia, Aditya
肿瘤
肿瘤免疫
信号转导
乳腺癌
免疫/内分泌
发表日期：2023
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A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies

加速癌症疗法发现与转化的协作模式

期刊:Cancer Research
影响因子:16.6
doi:10.1158/0008-5472.CAN-17-1789
Maertens, Ophélia; McCurrach, Mila E; Braun, Benjamin S; De Raedt, Thomas; Epstein, Inbal; Huang, Tannie Q; Lauchle, Jennifer O; Lee, Hyerim; Wu, Jianqiang; Cripe, Timothy P; Clapp, D Wade; Ratner, Nancy; Shannon, Kevin; Cichowski, Karen
肿瘤
肿瘤免疫
发表日期：2017
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Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

持续抑制MEK可消除Nf1突变小鼠的骨髓增生性疾病。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI85325
Chang, Tiffany; Krisman, Kimberly; Theobald, Emily Harding; Xu, Jin; Akutagawa, Jon; Lauchle, Jennifer O; Kogan, Scott; Braun, Benjamin S; Shannon, Kevin
发表日期：2016
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Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors

Apitolisib (GDC-0980) 是一种双重磷脂酰肌醇-3-激酶和哺乳动物雷帕霉素靶蛋白激酶抑制剂，用于治疗晚期实体瘤患者的 I 期研究

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-15-2225
Dolly, Saoirse O; Wagner, Andrew J; Bendell, Johanna C; Kindler, Hedy L; Krug, Lee M; Seiwert, Tanguy Y; Zauderer, Marjorie G; Lolkema, Martijn P; Apt, Doris; Yeh, Ru-Fang; Fredrickson, Jill O; Spoerke, Jill M; Koeppen, Hartmut; Ware, Joseph A; Lauchle, Jennifer O; Burris, Howard A 3rd; de Bono, Johann S
信号转导
发表日期：2016
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A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study)

一项针对复发性或持续性子宫内膜癌的 apitolisib (GDC-0980) 治疗的多中心、单臂、开放标签 II 期研究（MAGGIE 研究）

期刊:Cancer
影响因子:5.1
doi:10.1002/cncr.30286
Makker, Vicky; Recio, Fernando O; Ma, Ling; Matulonis, Ursula A; Lauchle, Jennifer O; Parmar, Hema; Gilbert, Houston N; Ware, Joseph A; Zhu, Rui; Lu, Shan; Huw, Ling-Yuh; Wang, Yulei; Koeppen, Hartmut; Spoerke, Jill M; Lackner, Mark R; Aghajanian, Carol A
MAG
肿瘤
子宫内膜癌
肿瘤免疫
发表日期：2016
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Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

持续抑制MEK可消除Nf1突变小鼠的骨髓增生性疾病。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI63193
Chang, Tiffany; Krisman, Kimberly; Theobald, Emily Harding; Xu, Jin; Akutagawa, Jon; Lauchle, Jennifer O; Kogan, Scott; Braun, Benjamin S; Shannon, Kevin
发表日期：2013
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A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice

MEK 抑制剂可治愈 Kras 突变小鼠的骨髓增生性疾病

期刊:Science Translational Medicine
影响因子:15.8
doi:10.1126/scitranslmed.3001069
Natalya Lyubynska, Matthew F Gorman, Jennifer O Lauchle, Wan Xing Hong, Jon K Akutagawa, Kevin Shannon, Benjamin S Braun
发表日期：2011
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Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

β 常见受体失活可减轻 Nf1 突变小鼠的骨髓增生性疾病

期刊:Blood
影响因子:21
doi:10.1182/blood-2006-05-025395
Andrew Kim, Kelly Morgan, Diane E Hasz, Stephen M Wiesner, Jennifer O Lauchle, Jennifer L Geurts, Miechaleen D Diers, Doan T Le, Scott C Kogan, Luis F Parada, Kevin Shannon, David A Largaespada
信号转导
发表日期：2007
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