日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned

基于 CRISPR 的 Vhl 缺陷型透明细胞肾癌小鼠模型:初步经验和教训

Laura A Stransky #, Wenhua Gao #, Laura S Schmidt #, Kevin Bi, Christopher J Ricketts, Vijyendra Ramesh, Amy James, Simone Difilippantonio, Lilia Ileva, Joseph D Kalen, Baktiar Karim, Albert Jeon, Tamara Morgan, Andrew C Warner, Sevilay Turan, Joanne Unite, Bao Tran, Sulbha Choudhari, Yongmei Zhao, 

Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway

VHL 突变肾癌对 HIF2 抑制剂的敏感性不需要完整的 p53 通路

Laura A Stransky, Sean M Vigeant, Bofu Huang, Destiny West, Thomas Denize, Emily Walton, Sabina Signoretti, William G Kaelin Jr

AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells

AKT Ser/Thr 激酶增加 V-ATPase 依赖性溶酶体酸化以响应哺乳动物细胞中的氨基酸饥饿

Michael P Collins, Laura A Stransky, Michael Forgac

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species

CDK4/6 抑制与 VHL 缺失之间的 HIF 独立合成致死率

Hilary E Nicholson, Zeshan Tariq, Benjamin E Housden, Rebecca B Jennings, Laura A Stransky, Norbert Perrimon, Sabina Signoretti, William G Kaelin Jr

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

氨基酸利用率调节液泡H+-ATPase组装

Laura A Stransky, Michael Forgac