日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PD1-IL2v expands and induces effector CD8(+) TILs, but not Tregs, in the BCG treated orthotopic non-muscle invasive bladder cancer model

在 BCG 治疗的原位非肌层浸润性膀胱癌模型中,PD1-IL2v 可扩增并诱导效应 CD8(+) TILs,但不诱导 Tregs。

Locatelli, Irene; Lorenzoni, Marco; Venegoni, Chiara; Di Coste, Alessia; Sorrentino, Rita; Jose, Jithin; Cirillo, Daniela Maria; Weber, Patrick; Manchala, Amrita; Hosse, Ralf J; Nicolini, Valeria; Umana, Pablo; Klein, Christian; Salonia, Andrea; Montorsi, Francesco; Bellone, Matteo; Moschini, Marco; Deak, Laura Codarri; Alfano, Massimo

Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

放射疗法同时靶向PD-1和IL-2Rβγ可抑制胰腺癌的生长和转移。

Miles Piper ,Maureen Hoen ,Laurel B Darragh ,Michael W Knitz ,Diemmy Nguyen ,Jacob Gadwa ,Greta Durini ,Idil Karakoc ,Abby Grier ,Brooke Neupert ,Benjamin Van Court ,Khalid N M Abdelazeem ,Justin Yu ,Nicholas A Olimpo ,Sophia Corbo ,Richard Blake Ross ,Tiffany T Pham ,Molishree Joshi ,Ross M Kedl ,Anthony J Saviola ,Maria Amann ,Pablo Umaña ,Laura Codarri Deak ,Christian Klein ,Angelo D'Alessandro ,Sana D Karam

Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

双特异性 PD1-IL2v 和抗 PD-L1 通过增强干细胞样肿瘤反应性 CD8+ T 细胞和重编程巨噬细胞来打破肿瘤免疫抵抗

Mélanie Tichet, Stephan Wullschleger, Agnieszka Chryplewicz, Nadine Fournier, Rachel Marcone, Annamaria Kauzlaric, Krisztian Homicsko, Laura Codarri Deak, Pablo Umaña, Christian Klein, Douglas Hanahan

Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

选择性靶向IL2Rβγ联合放射疗法可激活CD8和NK细胞介导的免疫反应,从而抑制头颈部鳞状细胞癌的转移。

Jacob Gadwa ,Maria Amann ,Thomas E Bickett ,Michael W Knitz ,Laurel B Darragh ,Miles Piper ,Benjamin Van Court ,Sanjana Bukkapatnam ,Tiffany T Pham ,Xiao-Jing Wang ,Anthony J Saviola ,Laura Codarri Deak ,Pablo Umaña ,Christian Klein ,Angelo D'Alessandro ,Sana D Karam

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

PD-1-顺式 IL-2R 激动剂可从干细胞样 CD8+ T 细胞中产生更好的效应物

Laura Codarri Deak #, Valeria Nicolini #, Masao Hashimoto #, Maria Karagianni #, Petra C Schwalie, Laura Lauener, Eleni Maria Varypataki, Marine Richard, Esther Bommer, Johannes Sam, Stefanie Joller, Mario Perro, Floriana Cremasco, Leo Kunz, Emilio Yanguez, Tamara Hüsser, Ramona Schlenker, Marisa Ma

Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors

解析人类肿瘤中双特异性抗体PD1-TIM3和PD1-LAG3的分子和细胞体外反应

Marina Natoli ,Klas Hatje ,Pratiksha Gulati # ,Fabian Junker # ,Petra Herzig ,Zhiwen Jiang ,Iakov I Davydov ,Markus Germann ,Marta Trüb ,Daniel Marbach ,Adrian Zwick ,Patrick Weber ,Stefan Seeber ,Mark Wiese ,Didier Lardinois ,Viola Heinzelmann-Schwarz ,Robert Rosenberg ,Lothar Tietze ,Kirsten D Mertz ,Pablo Umaña ,Christian Klein ,Laura Codarri-Deak ,Henry Kao # ,Alfred Zippelius #

A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1

一项用于测量既往接受过抗PD-1治疗的患者体内抗PD-1受体结合情况的人类受体占有率测定

Fabian Junker ,Pratiksha Gulati ,Uwe Wessels ,Stefan Seeber ,Kay-Gunnar Stubenrauch ,Laura Codarri-Deak ,Christoph Markert ,Christian Klein ,Priscila Camillo Teixeira ,Henry Kao