日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities

驯服白细胞介素-12:基于双特异性抗体的具有偏向激动能力的 IL-12 模拟物的工程设计

Britta Lipinski, Laura Unmuth, Paul Arras, Ron Endruszeit, Stefan Becker, Jonathan Mathias Rödel, Jürgen Scheller, Silke Pudewell, Doreen M Floss, Simon Krah, Julia Harwardt, Achim Doerner, Laura Helming, Chunxiao Xu, Andreas Menrad, Andreas Evers, Harald Kolmar, Desislava Elter, Lukas Pekar, Stefan

High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells

靶向髓系来源抑制细胞的化合物的高通量筛选和蛋白质组学表征

Johannes Krumm ,Elissaveta Petrova ,Severin Lechner ,Julia Mergner ,Hans-Henning Boehm ,Alessandro Prestipino ,Dominik Steinbrunn ,Marshall L Deline ,Lisa Koetzner ,Christina Schindler ,Laura Helming ,Tobias Fromme ,Martin Klingenspor ,Hannes Hahne ,Jan-Carsten Pieck ,Bernhard Kuster

Genetic screen in myeloid cells identifies TNF-α autocrine secretion as a factor increasing MDSC suppressive activity via Nos2 up-regulation

髓系细胞的基因筛选发现,TNF-α自分泌可通过上调Nos2来增强MDSC的抑制活性。

Matthias Schröder ,Marit Krötschel ,Lena Conrad ,Svenja Kerstin Naumann ,Christopher Bachran ,Alex Rolfe ,Viktor Umansky ,Laura Helming ,Lee Kim Swee

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency

免疫和胸腺蛋白酶体组装缺陷导致严重免疫缺陷

Irina Treise, Eva M Huber, Tanja Klein-Rodewald, Wolfgang Heinemeyer, Simon A Grassmann, Michael Basler, Thure Adler, Birgit Rathkolb, Laura Helming, Christian Andres, Matthias Klaften, Christina Landbrecht, Thomas Wieland, Tim M Strom, Kathy D McCoy, Andrew J Macpherson, Eckhard Wolf, Marcus Groett

The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent

髓系细胞特异性VHH免疫毒素的活性取决于靶点、表位、亚群和器官。

Christopher Bachran ,Matthias Schröder ,Lena Conrad ,Juan J Cragnolini ,Fikadu G Tafesse ,Laura Helming ,Hidde L Ploegh ,Lee Kim Swee

Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening

通过表型化学筛选鉴定髓系抑制细胞活性抑制剂

Matthias Schröder, Simone Loos, Svenja Kerstin Naumann, Christopher Bachran, Marit Krötschel, Viktor Umansky, Laura Helming, Lee Kim Swee

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans

小鼠和人类纤维化形成和纤维化消退过程中巨噬细胞表型的肝脏定位

Leonie Beljaars, Marlies Schippers, Catharina Reker-Smit, Fernando O Martinez, Laura Helming, Klaas Poelstra, Barbro N Melgert

The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion

清道夫受体 CD36 在细胞因子诱导的巨噬细胞融合中发挥作用

Laura Helming, Julia Winter, Siamon Gordon