日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1(Glu280Ala) mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial

在哥伦比亚,一项针对认知功能正常的、携带PSEN1(Glu280Ala)突变且有常染色体显性遗传阿尔茨海默病风险的人群的克雷尼珠单抗安全性和有效性研究(API ADAD Colombia试验):一项2期随机、双盲、安慰剂对照试验

Tariot, Pierre N; Lopera, Francisco S; Ríos-Romenets, Silvia; Sink, Kaycee M; Giraldo-Chica, Margarita; Acosta-Baena, Natalia; Villegas, Gustavo; Espinosa, Alejandro; Castaño, Marisol Londoño; Muñoz, Claudia; Ospina, Paula; Bocanegra, Yamile; Tirado, Victoria; Henao, Eliana; Cardona, Eugenia; Luna, Ernesto; Lopez, Hugo; Sánchez, Gregorio; Collazos, Mario Muñoz; Alvarez, Sergio; Aguillón, David; Hu, Nan; Clayton, David; Bittner, Tobias; Schneider, Andres; Dolton, Michael; Poon, Victor; Nguyen, Jonas; Thomas, Ronald G; Schneider, Lon S; Chen, Kewei; Su, Yi; Alexander, Robert C; Quiroz, Yakeel T; Cai, Yuqi; Xu, Yi Ran; Ostaszewski, Beth; Selkoe, Dennis J; Ashton, Nicholas J; Denkinger, Marisa N; Jakimovich, Laura J; Doody, Rachelle S; Langbaum, Jessica B; Reiman, Eric M

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer

负选择维持转移性结直肠癌中显著改变但总体稳定的核型

Cross, William C H; Nowinski, Salpie; Cresswell, George D; Mossner, Maximilian; Banerjee, Abhirup; Lu, Bingxin; Williams, Marc J; Vlachogiannis, Georgios; Gay, Laura J; Baker, Ann-Marie; Kimberley, Christopher; Whiting, Frederick J H; Belnoue-Davis, Hayley L; Martinez, Pierre; Traki, Maria; Walther, Viola; Smith, Kane; Fernandez-Mateos, Javier; Yara-Romero, Erika; Oliveira, Erica A; Milite, Salvatore; Caravagna, Giulio; James, Chela T; Elia, George; Berner, Alison; Ryan Choi, Chang-Ho; Ramagiri, Pradeep; Chauhan, Ritika; Matthews, Nik; Murphy, Jamie; Antoniou, Anthony; Clark, Susan K; Mitchison, Miriam; Chin Aleong, Jo-Anne; Domingo, Enric; Spiteri, Inmaculada; McDonald, Stuart A C; Shibata, Darryl; Laclé, Miangela M; Wang, Lai Mun; Moorghen, Morgan; Tomlinson, Ian P M; Novelli, Marco; Jansen, Marnix; Watson, Alan; Valeri, Nicola; Wright, Nicholas A; Bridgewater, John A; Rodriguez-Justo, Manuel; Barnes, Chris P; Kocher, Hemant M; Leedham, Simon J; Sottoriva, Andrea; Graham, Trevor A

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid-Responsive Ketal Side Groups

末端基团修饰的脂肪族聚碳酸酯与酸响应性缩酮侧基衍生的胶束免疫药物载体的展开和降解

Hauck, Adrian V; Fichter, Michael; Rosenberger, Laura J; Willig, Jannis; Fuchs, Alexander; Schön, Felicia; Schneider, Paul; Medina-Montano, Carolina; Ahmad, Taufiq; Erlenbusch, Jessica; Besenius, Pol; Kaps, Leonard; Bros, Matthias; Grabbe, Stephan; Mailänder, Volker; Groll, Jürgen; Nuhn, Lutz

Lifestyle Intervention for Sustained Remission of Metabolic Syndrome: A Randomized Clinical Trial

生活方式干预对代谢综合征持续缓解的影响:一项随机临床试验

Powell, Lynda H; Berkley-Patton, Jannette; Drees, Betty M; Karavolos, Kelly; Lohse, Barbara; Masters, Kevin S; Nicklas, Jacinda M; Rothschild, Steven K; Yeh, Chen; Zimmermann, Laura J; Suzuki, Sumihiro

Germline Pathogenic Variants Among Women Without a History of Breast Cancer: A Secondary Analysis of the WISDOM Randomized Clinical Trial

无乳腺癌病史女性的生殖系致病变异:WISDOM随机临床试验的二次分析

Fergus, Kirkpatrick B; Ross, Katherine S; Scheuner, Maren T; Blanco, Amie M; Tice, Jeffrey A; Ziv, Elad; Shieh, Yiwey; van 't Veer, Laura; Olopade, Olufunmilayo I; Goodman, Deborah L; Tong, Barry S; Harvey, Heather; DeRosa, Diana; Risty, Larissa; Silver, Erica; Kaster, Andrea; Fiscalini, Allison Stover; Blum, Kelly; Heise, Rachel; Sabacan, Leah; Heditsian, Diane; Brain, Susie; Petruse, Antonia; Eklund, Martin; Hiatt, Robert A; Borowsky, Alexander D; Naeim, Arash; Park, Hannah L; LaCroix, Andrea Z; Parker, Barbara A; Lancaster, Rachael; Esserman, James; Wenger, Neil; Arasu, Vignesh; Anton-Culver, Hoda; Esserman, Laura J; Madlensky, Lisa

Realizing Blume-Capel Degrees of Freedom with Toroidal Moments in a Ruby Artificial Spin Ice

利用红宝石人工自旋冰中的环形矩实现布鲁姆-卡佩尔自由度

Berchialla, Luca; Macauley, Gavin M; Museur, Flavien; Wang, Tianyue; Kleibert, Armin; Derlet, Peter M; Heyderman, Laura J

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

TBK1诱导Optineurin丝状体的形成,该丝状体与多聚泛素和LC3凝聚,从而隔离货物。

Herrera, Maria G; Kühn, Lena; Jungbluth, Lisa; Bader, Verian; Krause, Laura J; Kartte, David; Adriaenssens, Elias; Martens, Sascha; Tatzelt, Jörg; Sachse, Carsten; Winklhofer, Konstanze F

FBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome

FBXO11抑制重塑以NPM1为中心的相互作用组,从而影响骨髓增生异常综合征的进展。

Niederkorn, Madeline; Bezavada, Lavanya; Cotton, Anitria; Palmer, Lance E; Konada, Lahiri; Hall, Trent; Pagala, Vishwajeeth R; Zhai, Jinbin; Yuan, Zuo-Fei; Fu, Yingxue; Steele, Jacob A; Narina, Shilpa; Schild, Andrew; Wu, Chengzhou; Aminov, Sarah; Schieber, Michael; McGovern, Erin; Taylor, Aaron B; Gurbuxani, Sandeep; Xu, Peng; Ji, Peng; Janke, Laura J; High, Anthony A; Kang, Guolian; Pruett-Miller, Shondra M; Weiss, Mitchell; Verma, Amit; Rampal, Raajit K; Crispino, John D

A specific amount of RamA must be reached to trigger increased expression of AcrAB, enhance efflux, and confer multidrug resistance

必须达到特定量的RamA才能触发AcrAB表达增加、增强外排作用并赋予多药耐药性。

Ricci, Vito; Piddock, Laura J V

Global trends in clozapine utilisation between 2014 and 2024: a longitudinal epidemiological study with data from 75 countries

2014年至2024年氯氮平使用情况的全球趋势:一项基于75个国家数据的纵向流行病学研究

Fitzgerald, Ita; O'Dwyer, Sarah; Dhubhlaing, Ciara Ní; Gee, Siobhan; Sahm, Laura J; Wheeler, Amanda; Hurley, Eoin; Saastamoinen, Leena; Waksmundzka-Walczuk, Anna; Donohue, Grainne; Shiers, David; Gupta, Veenu; Howe, Jo; Correll, Christoph U; Højlund, Mikkel