日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration

实验性肺纤维化分子影像学研究显示,尼达尼布出乎意料地调节了CCR2免疫细胞的浸润。

Hasan Farooq ,Hannah P Luehmann ,Jeffrey R Koenitzer ,Gyu Seong Heo ,Deborah H Sultan ,Devesha H Kulkarni ,Sean P Gunsten ,Rekha M Sashti ,Tao Huang ,Amanda R Keller ,Kory J Lavine ,Jeffrey J Atkinson ,Laura M Wingler ,Yongjian Liu ,Steven L Brody

Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

纳米抗体介导的血管紧张素受体双重空间位阻结合拓宽了偏向性配体药理学

Nayara Braga Emidio ,Brandi M Small ,Amanda R Keller ,Ross W Cheloha ,Laura M Wingler

Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways

AT1R C 末端的磷酸化模式决定了不同的下游信号通路

Clarice Gareri, Conrad T Pfeiffer, Xue Jiang, Joao A Paulo, Steven P Gygi, Uyen Pham, Anand Chundi, Laura M Wingler, Dean P Staus, Tomasz Maciej Stepniewski, Jana Selent, Emilio Y Lucero, Alyssa Grogan, Sudarshan Rajagopal, Howard A Rockman

Antibodies Expand the Scope of Angiotensin Receptor Pharmacology

抗体扩大了血管紧张素受体药理学的范围

Meredith A Skiba, Sarah M Sterling, Shaun Rawson, Morgan S A Gilman, Huixin Xu, Genevieve R Nemeth, Joseph D Hurley, Pengxiang Shen, Dean P Staus, Jihee Kim, Conor McMahon, Maria K Lehtinen, Laura M Wingler, Andrew C Kruse

Rapid generation of potent antibodies by autonomous hypermutation in yeast

酵母自主超突变快速产生强效抗体

Alon Wellner # ,Conor McMahon # ,Morgan S A Gilman ,Jonathan R Clements ,Sarah Clark ,Kianna M Nguyen ,Ming H Ho ,Vincent J Hu ,Jung-Eun Shin ,Jared Feldman ,Blake M Hauser ,Timothy M Caradonna ,Laura M Wingler ,Aaron G Schmidt ,Debora S Marks ,Jonathan Abraham ,Andrew C Kruse ,Chang C Liu

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

脂质纳米盘中 M2 毒蕈碱受体-β-抑制蛋白复合物的结构

Dean P Staus #, Hongli Hu #, Michael J Robertson #, Alissa L W Kleinhenz, Laura M Wingler, William D Capel, Naomi R Latorraca, Robert J Lefkowitz, Georgios Skiniotis

Synthetic nanobodies as angiotensin receptor blockers

合成纳米抗体作为血管紧张素受体阻滞剂

Conor McMahon, Dean P Staus, Laura M Wingler, Jialu Wang, Meredith A Skiba, Matthias Elgeti, Wayne L Hubbell, Howard A Rockman, Andrew C Kruse, Robert J Lefkowitz

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

合成纳米抗体揭示血管紧张素受体的独特激活机制

Laura M Wingler ,Conor McMahon ,Dean P Staus ,Robert J Lefkowitz ,Andrew C Kruse

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library

从 DNA 编码的小分子库中分离出的变构“β受体阻滞剂”

Seungkirl Ahn, Alem W Kahsai, Biswaranjan Pani, Qin-Ting Wang, Shuai Zhao, Alissa L Wall, Ryan T Strachan, Dean P Staus, Laura M Wingler, Lillian D Sun, Justine Sinnaeve, Minjung Choi, Ted Cho, Thomas T Xu, Gwenn M Hansen, Michael B Burnett, Jane E Lamerdin, Daniel L Bassoni, Bryant J Gavino, Gitte

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

构象选择性 RNA 适体变构调节 β2-肾上腺素能受体

Alem W Kahsai, James W Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J Cahill Iii, S Moses Dennison, Dean P Staus, Alex R B Thomsen, Kara M Anasti, Biswaranjan Pani, Laura M Wingler, Hemant Desai, Kristin M Bompiani, Ryan T Strachan, Xiaoxia Qin, S Munir Alam, Bruce A Sullenger, Robert J Lefkowitz1