Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome.
胱硫醚β-合成酶的缺失导致氧化磷酸化水平升高，这是唐氏综合征中阿糖胞苷耐药性髓系白血病的一个弱点。
期刊:Biochemical Pharmacology
影响因子:5.6
doi:10.1016/j.bcp.2026.117815
Thibodeau Jenna, Zhao Jianlei, Edwards Holly, Polin Lisa, Kushner Juiwanna, Dzinic Sijana H, White Kathryn, Hershberger Kian, Su Yongwei, Arroum Tasnim, Pham Lucynda, Pavelich Lauren, Awdish Raina, LaValley Jacob, Boucher Austin C, Chen Wei, Li Jing, Bao Xun, Hüttemann Maik, Back Jessica B, Allen Joshua E, Prabhu Varun V, Crispino John D, Taub Jeffrey W, Ge Yubin
