日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Probing the extent of importin-α targeting of the TAF8 NLS by eliminating its cationic net-charge.

通过消除其阳离子净电荷来探测输入蛋白α对TAF8 NLS的靶向程度

Abdoli Amirabbas, Yang Zhihan, Odeh-Ahmed Abdullah, Bednova Olga, Lemieux Bruno, Dawe Leanne, Ravel-Chapuis Aymeric, Lavigne Pierre, Zeytuni Natalie, Leyton Jeffrey V

A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes

一种复发的从头 MAX p.Arg60Gln 变异通过 c-Myc 靶基因的差异表达导致综合征性过度生长障碍。

Harris, Erica L; Roy, Vincent; Montagne, Martin; Rose, Ailsa M S; Livesey, Helen; Reijnders, Margot R F; Hobson, Emma; Sansbury, Francis H; Willemsen, Marjolein H; Pfundt, Rolph; Warren, Daniel; Long, Vernon; Carr, Ian M; Brunner, Han G; Sheridan, Eamonn G; Firth, Helen V; Lavigne, Pierre; Poulter, James A

Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice

卵母细胞中 Exosc10 的失活会损害卵母细胞的发育和成熟,导致小鼠卵巢储备的耗尽

Leïla Demini, Christine Kervarrec, Laëtitia Guillot, Emmanuelle Com, Régis Lavigne, Pierre-Yves Kernanec, Michael Primig, Charles Pineau, Fabrice G Petit, Soazik P Jamin

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System

订书肽环化技术的比较分析:SARS-CoV-2 Spike RBD/hACE2 模型系统中蛋白质-蛋白质相互作用的结构洞察

Sára Ferková, Ulrike Froehlich, Marie-Édith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

奥莫霉素(Omomyc)的内在细胞穿透活性使其从概念验证阶段发展成为可行的抗MYC疗法。

Beaulieu, Marie-Eve; Jauset, Toni; Massó-Vallés, Daniel; Martínez-Martín, Sandra; Rahl, Peter; Maltais, Loïka; Zacarias-Fluck, Mariano F; Casacuberta-Serra, Sílvia; Serrano Del Pozo, Erika; Fiore, Christopher; Foradada, Laia; Cano, Virginia Castillo; Sánchez-Hervás, Meritxell; Guenther, Matthew; Romero Sanz, Eduardo; Oteo, Marta; Tremblay, Cynthia; Martín, Génesis; Letourneau, Danny; Montagne, Martin; Morcillo Alonso, Miguel Ángel; Whitfield, Jonathan R; Lavigne, Pierre; Soucek, Laura

Gα(s) protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting

Gα(s)蛋白结合泛素以调节表皮生长因子受体内体分选

Li, Xuezhi; Létourneau, Danny; Holleran, Brian; Leduc, Richard; Lavigne, Pierre; Lavoie, Christine

STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism

类固醇化的STARD6:溶液结构、多时间尺度骨架动力学和配体结合机制

Létourneau, Danny; Bédard, Mikaël; Cabana, Jérôme; Lefebvre, Andrée; LeHoux, Jean-Guy; Lavigne, Pierre

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.

利用分子动力学模拟鉴定与 Gq/11 蛋白通路和 β-阻遏蛋白通路相关的血管紧张素 II 1 型受体的不同构象

Cabana Jérôme, Holleran Brian, Leduc Richard, Escher Emanuel, Guillemette Gaétan, Lavigne Pierre

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival

GGA3介导TrkA内吞循环,从而促进Akt持续磷酸化和细胞存活。

Li, Xuezhi; Lavigne, Pierre; Lavoie, Christine

Structure of the human angiotensin II type 1 (AT1) receptor bound to angiotensin II from multiple chemoselective photoprobe contacts reveals a unique peptide binding mode.

通过多个化学选择性光探针接触,揭示了与血管紧张素 II 结合的人类血管紧张素 II 1 型 (AT1) 受体的结构,展现了一种独特的肽结合模式

Fillion Dany, Cabana Jérôme, Guillemette Gaétan, Leduc Richard, Lavigne Pierre, Escher Emanuel