Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia
对6,7-二氢吡唑并[1,5-a]吡嗪-4-酮衍生物作为一类新型mGlu5受体正向变构调节剂的初步研究，该类化合物在精神分裂症的临床前模型中显示出疗效
期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2015.11.098
Conde-Ceide, Susana; Alcázar, Jesús; Alonso de Diego, Sergio A; López, Silvia; Martín-Martín, María Luz; Martínez-Viturro, Carlos M; Pena, Miguel-Angel; Tong, Han Min; Lavreysen, Hilde; Mackie, Claire; Bridges, Thomas M; Daniels, J Scott; Niswender, Colleen M; Jones, Carrie K; Macdonald, Gregor J; Steckler, Thomas; Conn, P Jeffrey; Stauffer, Shaun R; Lindsley, Craig W; Bartolomé-Nebreda, José Manuel
