日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation

CD28 通过调节 Lck 动态变化和 ZAP70 活化来调控 T 细胞受体信号传导。

Kumarkrishna Raychaudhuri ,Rohita Rangu ,Alison Ma ,Neriah Alvinez ,Andy D Tran ,Sandeep Pallikkuth ,Katherine M McIntire ,Joseph A Garvey ,Jason Yi ,Lawrence E Samelson

Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs

结合 T 细胞信号传导基序的抗肿瘤嵌合抗原受体的产生

Lakshmi Balagopalan, Taylor Moreno, Haiying Qin, Benjamin C Angeles, Taisuke Kondo, Jason Yi, Katherine M McIntire, Neriah Alvinez, Sandeep Pallikkuth, Mariah E Lee, Hidehiro Yamane, Andy D Tran, Philippe Youkharibache, Raul E Cachau, Naomi Taylor, Lawrence E Samelson

Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling

遗传性ARPC5突变会导致肌动蛋白病,损害细胞运动能力并破坏细胞因子信号传导。

Cristiane J Nunes-Santos ,HyeSun Kuehn ,Brigette Boast ,SuJin Hwang ,Douglas B Kuhns ,Jennifer Stoddard ,Julie E Niemela ,Danielle L Fink ,Stefania Pittaluga ,Mones Abu-Asab ,John S Davies ,Valarie A Barr ,Tomoki Kawai ,Ottavia M Delmonte ,Marita Bosticardo ,Mary Garofalo ,Magda Carneiro-Sampaio ,Raz Somech ,Mohammad Gharagozlou ,Nima Parvaneh ,Lawrence E Samelson ,Thomas A Fleisher ,Anne Puel ,Luigi D Notarangelo ,Bertrand Boisson ,Jean-Laurent Casanova ,Beata Derfalvi ,Sergio D Rosenzweig

Heterogeneity of Signaling Complex Nanostructure in T Cells Activated Via the T Cell Antigen Receptor

通过 T 细胞抗原受体激活的 T 细胞信号复合物纳米结构的异质性

Valarie A Barr, Juan Piao, Lakshmi Balagopalan, Katherine M McIntire, Frederic P Schoenberg, Lawrence E Samelson

In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells

体外重建揭示了衔接蛋白介导的T细胞中磷脂酶C-γ1激活的协同机制

Junya Wada, Udumbara Rathnayake, Lisa M Jenkins, Avinash Singh, Moosa Mohammadi, Ettore Appella, Paul A Randazzo, Lawrence E Samelson

Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components

TMC6-TMC8-CIB1 异三聚体复合物在淋巴细胞中的表达受各成分的调节

Chuan-Jin Wu, Xing Li, Connie L Sommers, Kiyoto Kurima, Sunmee Huh, Grace Bugos, Lijin Dong, Wenmei Li, Andrew J Griffith, Lawrence E Samelson

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

TCR 微簇形成空间隔离域,并按照钙依赖性动力学步骤依次组装

Jason Yi, Lakshmi Balagopalan, Tiffany Nguyen, Katherine M McIntire, Lawrence E Samelson

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

质膜 LAT 激活先于囊泡募集,决定了早期 T 细胞激活的两个阶段

Lakshmi Balagopalan, Jason Yi, Tiffany Nguyen, Katherine M McIntire, Adam S Harned, Kedar Narayan, Lawrence E Samelson

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells

Cish SH2结构域对于TCR刺激的CD8+ T细胞中PLC-γ1的调控至关重要

Geoffrey Guittard ,Ana Dios-Esponera ,Douglas C Palmer ,Itoro Akpan ,Valarie A Barr ,Asit Manna ,Nicholas P Restifo ,Lawrence E Samelson

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome

TCR 信号的强度和持续时间受到 ZAP-70T293 的 p38 磷酸化和信号体不稳定的限制

Maria Letizia Giardino Torchia, Debjani Dutta, Paul R Mittelstadt, June Guha, Matthias M Gaida, Kamonwan Fish, Valarie A Barr, Itoro O Akpan, Lawrence E Samelson, Harichandra D Tagad, Subrata Debnath, Lisa M Miller Jenkins, Ettore Appella, Jonathan D Ashwell