日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial

疟疾疫苗对皮内或静脉寄生虫的保护作用:一项随机 2b 期人体挑战试验

Kapulu, Melissa C; Orenge, Francesca; Kimani, Domtila; Kibwana, Elizabeth; Kibet, Hillary; Mutahi, Mary; Datoo, Mehreen S; Bellamy, Duncan; Musembi, Janet; Ngoto, Omar; Rashid, Hamisi; Akinyi, Stellamaris; Mwatasa, Mwaganyuma H; Nyamako, Lydia; Keter, Kelvias; Gatheru, Rose; Mutiso, Agnes; Musyoki, Jennifer; Mwacharo, Jedidah; Abebe, Yonas; James, Eric R; Billingsley, Peter F; Ngetsa, Caroline; Mosobo, Moses; Makale, Johnstone; Tawa, Brian; Wamae, Kevin; Ochola-Oyier, Lynette I; Lawrie, Alison; Ramos-Lopez, Fernando; Roberts, Rachel; Richie, Thomas L; Sim, B Kim Lee; Hoffman, Stephen L; Ewer, Katie J; Hill, Adrian V S; Hamaluba, Mainga; Bejon, Philip

R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial

R21/Matrix-M疟疾疫苗在既往感染过疟疾的成年人中诱发多种免疫反应:一项IIb期对照人体疟疾感染试验的启示

Kibwana, Elizabeth; Bundi, Caroline; Kimani, Domtila; Nyamako, Lydia; Keter, Kelvias; Mutiso, Agnes; Ogwang, Rodney; Bellamy, Duncan; Rapi, Katerina; Bajer, Amelia; Provstgaard-Morys, Samuel; Stockdale, Lisa; Munoz, Olivia; Datoo, Mehreen S; Lawrie, Alison; Ramos-Lopez, Fernando; Roberts, Rachel; Hamaluba, Mainga; Hill, Adrian V S; Bejon, Philip; Ewer, Katie J; Kapulu, Melissa

Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial

疟疾候选疫苗R21/Matrix-M在非洲儿童中的安全性和有效性:一项多中心、双盲、随机、3期试验

Datoo, Mehreen S; Dicko, Alassane; Tinto, Halidou; Ouédraogo, Jean-Bosco; Hamaluba, Mainga; Olotu, Ally; Beaumont, Emma; Ramos Lopez, Fernando; Natama, Hamtandi Magloire; Weston, Sophie; Chemba, Mwajuma; Compaore, Yves Daniel; Issiaka, Djibrilla; Salou, Diallo; Some, Athanase M; Omenda, Sharon; Lawrie, Alison; Bejon, Philip; Rao, Harish; Chandramohan, Daniel; Roberts, Rachel; Bharati, Sandesh; Stockdale, Lisa; Gairola, Sunil; Greenwood, Brian M; Ewer, Katie J; Bradley, John; Kulkarni, Prasad S; Shaligram, Umesh; Hill, Adrian V S

Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial

RH5.1/Matrix-M 是一种血液期疟疾候选疫苗,在坦桑尼亚健康成人和儿童中进行评估;这是一项开放标签、非随机、首次人体试验、单中心、1b期临床试验。

Silk, Sarah E; Kalinga, Wilmina F; Salkeld, Jo; Mtaka, Ivanny M; Ahmed, Saumu; Milando, Florence; Diouf, Ababacar; Bundi, Caroline K; Balige, Neema; Hassan, Omar; Mkindi, Catherine G; Rwezaula, Stella; Athumani, Thabit; Mswata, Sarah; Lilolime, Nasoro S; Simon, Beatus; Msami, Hania; Mohamed, Mohamed; David, Damiano M; Mohammed, Latipha; Nyaulingo, Gloria; Mwalimu, Bakari; Juma, Omary; Mwamlima, Tunu G; Sasamalo, Ibrahim A; Mkumbange, Rose P; Kamage, Janeth J; Barrett, Jordan R; King, Lloyd D W; Hou, Mimi M; Pulido, David; Carnrot, Cecilia; Lawrie, Alison M; Cowan, Rachel E; Nugent, Fay L; Roberts, Rachel; Cho, Jee-Sun; Long, Carole A; Nielsen, Carolyn M; Miura, Kazutoyo; Draper, Simon J; Olotu, Ally I; Minassian, Angela M

Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-escalation, randomised, controlled, phase 1 trial

在英国一项剂量递增、随机、对照的1期临床试验中,比较了气溶胶吸入减毒活牛分枝杆菌卡介苗与皮内注射卡介苗在未接种过卡介苗的成年人中感染结核病的安全性:一项受控的人体感染模型研究

Satti, Iman; Marshall, Julia L; Harris, Stephanie A; Wittenberg, Rachel; Tanner, Rachel; Lopez Ramon, Raquel; Wilkie, Morven; Ramos Lopez, Fernando; Riste, Michael; Wright, Daniel; Peralta Alvarez, Marco Polo; Williams, Nicola; Morrison, Hazel; Stylianou, Elena; Folegatti, Pedro; Jenkin, Daniel; Vermaak, Samantha; Rask, Linnea; Cabrera Puig, Ingrid; Powell Doherty, Rebecca; Lawrie, Alison; Moss, Paul; Hinks, Timothy; Bettinson, Henry; McShane, Helen

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults

一项 I/IIa 期研究旨在评估 ChAdOx1-MVA 载体疫苗(表达一种新型肝期疟疾双抗原 LS2)在未感染过疟疾的成年人中通过孢子攻击的安全性、免疫原性和有效性。

Silman, Daniel; Flaxman, Amy; Datoo, Mehreen; Edwards, Nick J; Ramos-Lopez, Fernando; Mitton, Celia; Mair, Catherine; Bellamy, Duncan; Bowyer, Georgina; Morter, Richard; Halbroth, Benedict; Venkatraman, Navin; Folegatti, Pedro M; Marshall, Julia; Poulton, Ian; Bajer, Amelia; Salman, Ahmed M; Berrie, Eleanor; Baum, Jake; Blagborough, Andrew M; Crocker, Wendy; Roberts, Rachel; Lawrie, Alison M; Spencer, Alexandra J; Gilbert, Sarah C; Ewer, Katie J; Hill, Adrian V S

Safety and immunogenicity of a ChAdOx1 vaccine against Rift Valley fever in UK adults: an open-label, non-randomised, first-in-human phase 1 clinical trial

ChAdOx1疫苗在英国成人中预防裂谷热的安全性和免疫原性:一项开放标签、非随机、首次人体I期临床试验

Jenkin, Daniel; Wright, Daniel; Folegatti, Pedro M; Platt, Abigail; Poulton, Ian; Lawrie, Alison; Tran, Nguyen; Boyd, Amy; Turner, Cheryl; Gitonga, John N; Karanja, Henry K; Mugo, Daisy; Ewer, Katie J; Bowden, Thomas A; Gilbert, Sarah C; Charleston, Bryan; Kaleebu, Pontiano; Hill, Adrian V S; Warimwe, George M

Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection

接种间日疟原虫杜菲结合蛋白疫苗可抑制受控人类疟疾感染期间的寄生虫生长

Hou, Mimi M; Barrett, Jordan R; Themistocleous, Yrene; Rawlinson, Thomas A; Diouf, Ababacar; Martinez, Francisco J; Nielsen, Carolyn M; Lias, Amelia M; King, Lloyd D W; Edwards, Nick J; Greenwood, Nicola M; Kingham, Lucy; Poulton, Ian D; Khozoee, Baktash; Goh, Cyndi; Hodgson, Susanne H; Mac Lochlainn, Dylan J; Salkeld, Jo; Guillotte-Blisnick, Micheline; Huon, Christèle; Mohring, Franziska; Reimer, Jenny M; Chauhan, Virander S; Mukherjee, Paushali; Biswas, Sumi; Taylor, Iona J; Lawrie, Alison M; Cho, Jee-Sun; Nugent, Fay L; Long, Carole A; Moon, Robert W; Miura, Kazutoyo; Silk, Sarah E; Chitnis, Chetan E; Minassian, Angela M; Draper, Simon J

Safety and immunogenicity of varied doses of R21/Matrix-M™ vaccine at three years follow-up: A phase 1b age de-escalation, dose-escalation trial in adults, children, and infants in Kilifi-Kenya

R21/Matrix-M™疫苗不同剂量在三年随访中的安全性和免疫原性:一项在肯尼亚基利菲进行的成人、儿童和婴儿的1b期年龄递减、剂量递增试验

Sang, Samuel; Datoo, Mehreen S; Otieno, Edward; Muiruri, Charles; Bellamy, Duncan; Gathuri, Emmaloise; Ngoto, Omar; Musembi, Janet; Provstgaard-Morys, Sam; Stockdale, Lisa; Aboagye, Jeremy; Woods, Daniel; Lawrie, Alison; Roberts, Racheal; Keter, Kelvias; Kimani, Domtila; Ndungu, Francis; Kapulu, Melissa; Njau, Irene; Orindi, Benedict; Ewer, Katie J; Hill, Adrian V S; Bejon, Philip; Hamaluba, Mainga

Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics

对英国健康成年人进行重复控制的人类疟疾感染(感染血液期恶性疟原虫):安全性和寄生虫生长动态

Salkeld, Jo; Themistocleous, Yrene; Barrett, Jordan R; Mitton, Celia H; Rawlinson, Thomas A; Payne, Ruth O; Hou, Mimi M; Khozoee, Baktash; Edwards, Nick J; Nielsen, Carolyn M; Sandoval, Diana Muñoz; Bach, Florian A; Nahrendorf, Wiebke; Ramon, Raquel Lopez; Baker, Megan; Ramos-Lopez, Fernando; Folegatti, Pedro M; Quinkert, Doris; Ellis, Katherine J; Poulton, Ian D; Lawrie, Alison M; Cho, Jee-Sun; Nugent, Fay L; Spence, Philip J; Silk, Sarah E; Draper, Simon J; Minassian, Angela M