日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis

发现莱那卡帕韦:首个用于 HIV-1 治疗和暴露前预防的每年两次给药的衣壳抑制剂

Canales, Eda; Tse, Winston; Schroeder, Scott D; Chou, Chien-Hung; Liu, Qi; Zhang, Jennifer; Lazerwith, Scott E; Morganelli, Philip; Saito, Roland D; Brizgys, Gediminas; Li, Jiayao; Wu, Qiaoyin; Graupe, Michael; Halcomb, Randall L; Desai, Manoj; Cannizzaro, Carina; Hu, Eric; Perry, Jason K; Villaseñor, Armando G; Somoza, John R; Ferrao, Ryan D; Swaminathan, S; Zheng, Jim; Lu, Bing; Mwangi, Judy; Wang, Kelly; Subramanian, Raju; Smith, Bill J; Rhodes, Gerry; Rowe, William; Sauer, Dorothea; Lad, Latesh; Papalia, Giuseppe A; Clancy, Sheila; Stepan, George J; Yu, Helen; Sakowicz, Roman; Shi, Bing; Carr, Gavin; Bam, Rujuta A; Tsai, Luong K; Singer, Eric; Hansen, Derek; Mulato, Andrew; Yant, Stephen R; Cihlar, Tomas; Link, John O

Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes

比克替拉韦与HIV-1整合酶-DNA复合物的长期解离

White, Kirsten L; Osman, Nathan; Cuadra-Foy, Ernesto; Brenner, Bluma G; Shivakumar, Devleena; Campigotto, Federico; Tsiang, Manuel; Morganelli, Philip A; Novikov, Nikolai; Lazerwith, Scott E; Jin, Haolun; Niedziela-Majka, Anita

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

比克替拉韦 (GS-9883) 的抗病毒活性,这是一种新型强效 HIV-1 整合酶链转移抑制剂,具有改进的抗药性

Manuel Tsiang, Gregg S Jones, Joshua Goldsmith, Andrew Mulato, Derek Hansen, Elaine Kan, Luong Tsai, Rujuta A Bam, George Stepan, Kirsten M Stray, Anita Niedziela-Majka, Stephen R Yant, Helen Yu, George Kukolj, Tomas Cihlar, Scott E Lazerwith, Kirsten L White, Haolun Jin

A small-molecule inhibitor of hepatitis C virus infectivity

丙型肝炎病毒感染的小分子抑制剂

Caroline O Bush, Maria V Pokrovskii, Roland Saito, Philip Morganelli, Eda Canales, Michael O Clarke, Scott E Lazerwith, Justin Golde, Brian G Reid, Kerim Babaoglu, Nikos Pagratis, Weidong Zhong, William E Delaney 4th, Matthew S Paulson, Rudolf K F Beran

Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase

GS-9669(丙型肝炎病毒 NS5B 聚合酶拇指位点 II 抑制剂)的临床前表征

Martijn Fenaux, Stacey Eng, Stephanie A Leavitt, Yu-Jen Lee, Eric M Mabery, Yang Tian, Daniel Byun, Eda Canales, Michael O Clarke, Edward Doerffler, Scott E Lazerwith, Willard Lew, Qi Liu, Michael Mertzman, Philip Morganelli, Lianhong Xu, Hong Ye, Jennifer Zhang, Mike Matles, Bernard P Murray, Judy

Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid

补体 1s 是一种丝氨酸蛋白酶,可裂解人类骨关节炎关节液中的 IGFBP-5

W H Busby Jr, S A Yocum, M Rowland, D Kellner, S Lazerwith, F Sverdrup, M Yates, M Radabaugh, D R Clemmons

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

苯并噻吩、哌嗪和哌啶脲类脂肪酸酰胺水解酶(FAAH)抑制剂

Johnson, Douglas S; Ahn, Kay; Kesten, Suzanne; Lazerwith, Scott E; Song, Yuntao; Morris, Mark; Fay, Lorraine; Gregory, Tracy; Stiff, Cory; Dunbar, James B Jr; Liimatta, Marya; Beidler, David; Smith, Sarah; Nomanbhoy, Tyzoon K; Cravatt, Benjamin F

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain

发现并表征一种可减轻炎症疼痛的高选择性 FAAH 抑制剂

Kay Ahn, Douglas S Johnson, Mauro Mileni, David Beidler, Jonathan Z Long, Michele K McKinney, Eranthie Weerapana, Nalini Sadagopan, Marya Liimatta, Sarah E Smith, Scott Lazerwith, Cory Stiff, Satwik Kamtekar, Keshab Bhattacharya, Yanhua Zhang, Stephen Swaney, Keri Van Becelaere, Raymond C Stevens, B