日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhanced lysosomal activity prevents infection with PrP(Sc) and the seeding activity of α-synuclein & tau prions

溶酶体活性增强可阻止 PrP(Sc) 感染以及 α-突触核蛋白和 tau 朊病毒的播散活性。

Mercer, Robert C C; Le, Nhat T T; Mirza-Romero, Nadia A; Orbe, Isabel C; Flaherty, Erin; DeFranco, Joseph P; Lavigna, Giada; Gatdula, Jean R P; Fraser, Douglas G; Sundaravadivelu, Aravind; Vultaggio, Janelle S; Beeler, Aaron B; Chiesa, Roberto; Telling, Glenn C; Harris, David A

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

化学组学流程能够发现朊病毒突触毒性通路和抑制药物

Le, Nhat T T; Mercer, Robert C C; Fang, Cheng; Sundaravadivelu, Aravind; Labadorf, Adam T; Lin, Weiwei; Kwan, Julian; Blum, Benjamin; Emili, Andrew; Harris, David A

A Human Neuronal Co-Culture System Reveals Early Tumor-Neuron Communication and Targetable Pathways in Glioblastoma

人类神经元共培养系统揭示胶质母细胞瘤早期肿瘤-神经元通讯及可靶向通路

Nebie, Ouada; Adelakun, Niyi; Zhang, Liwen; Kollin, Luke; Fries, Brian; Medikonda, Akhil; Venere, Monica; Giglio, Pierre; Chu, Nam; Le, Nhat T

Lysosomal Enhancement Prevents Infection with PrP(Sc), α-Synuclein & Tau Prions.

溶酶体增强可预防 PrP(Sc)、α-突触核蛋白和 Tau 朊病毒的感染

Mercer Robert C C, Le Nhat T T, Mirza-Romero Nadia A, Flaherty Erin, DeFranco Joseph P, Lavigna Giada, Orbe Isabel C, Gatdula Jean R P, Fraser Douglas G, Sundaravadivelu Aravind, Vultaggio Janelle S, Beeler Aaron B, Chiesa Roberto, Telling Glenn C, Harris David A

Prion protein pathology in Ubiquilin 2 models of ALS.

泛素连接酶 2 型 ALS 模型中的朊病毒蛋白病理

Le Nhat T, Chu Nam, Joshi Gunjan, Higgins Nicole R, Nebie Ouada, Adelakun Niyi, Butts Marie, Monteiro Mervyn J

Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease

来自患有遗传性克雅氏病的多代家族的iPSC衍生神经元中突触结构异常

Gojanovich, Aldana D; Le, Nhat T T; Mercer, Robert C C; Park, Seonmi; Wu, Bei; Anane, Alice; Vultaggio, Janelle S; Mostoslavsky, Gustavo; Harris, David A

Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding.

Sigma受体配体是强效的抗朊病毒化合物,其作用不依赖于Sigma受体结合

Mercer Robert C C, Le Nhat T T, Fraser Douglas G, Houser Mei C Q, Beeler Aaron B, Harris David A

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations

表达与 ALS-FTD 相关的 UBQLN2 突变的小鼠出现运动神经元疾病、TDP-43 病理和记忆缺陷

Le, Nhat T T; Chang, Lydia; Kovlyagina, Irina; Georgiou, Polymnia; Safren, Nathaniel; Braunstein, Kerstin E; Kvarta, Mark D; Van Dyke, Adam M; LeGates, Tara A; Philips, Thomas; Morrison, Brett M; Thompson, Scott M; Puche, Adam C; Gould, Todd D; Rothstein, Jeffrey D; Wong, Philip C; Monteiro, Mervyn J