Le Nhat T T相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Enhanced lysosomal activity prevents infection with PrP(Sc) and the seeding activity of α-synuclein & tau prions

溶酶体活性增强可阻止 PrP(Sc) 感染以及 α-突触核蛋白和 tau 朊病毒的播散活性。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2025.111050

Mercer, Robert C C; Le, Nhat T T; Mirza-Romero, Nadia A; Orbe, Isabel C; Flaherty, Erin; DeFranco, Joseph P; Lavigna, Giada; Gatdula, Jean R P; Fraser, Douglas G; Sundaravadivelu, Aravind; Vultaggio, Janelle S; Beeler, Aaron B; Chiesa, Roberto; Telling, Glenn C; Harris, David A

发表日期：2026

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Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

化学组学流程能够发现朊病毒突触毒性通路和抑制药物

doi:10.64898/2026.01.28.702331

Le, Nhat T T; Mercer, Robert C C; Fang, Cheng; Sundaravadivelu, Aravind; Labadorf, Adam T; Lin, Weiwei; Kwan, Julian; Blum, Benjamin; Emili, Andrew; Harris, David A

发表日期：2026

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Lysosomal Enhancement Prevents Infection with PrP(Sc), Î±-Synuclein & Tau Prions.

溶酶体增强可预防 PrP(Sc)、α-突触核蛋白和 Tau 朊病毒的感染

doi:10.1101/2025.06.24.661349

Mercer Robert C C, Le Nhat T T, Mirza-Romero Nadia A, Flaherty Erin, DeFranco Joseph P, Lavigna Giada, Orbe Isabel C, Gatdula Jean R P, Fraser Douglas G, Sundaravadivelu Aravind, Vultaggio Janelle S, Beeler Aaron B, Chiesa Roberto, Telling Glenn C, Harris David A

免疫/内分泌

发表日期：2025

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Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease

来自患有遗传性克雅氏病的多代家族的iPSC衍生神经元中突触结构异常

期刊:Stem Cell Reports

影响因子:5.1

doi:10.1016/j.stemcr.2024.08.010

Gojanovich, Aldana D; Le, Nhat T T; Mercer, Robert C C; Park, Seonmi; Wu, Bei; Anane, Alice; Vultaggio, Janelle S; Mostoslavsky, Gustavo; Harris, David A

发表日期：2024

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Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding.

Sigma受体配体是强效的抗朊病毒化合物，其作用不依赖于Sigma受体结合

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.4c00095

Mercer Robert C C, Le Nhat T T, Fraser Douglas G, Houser Mei C Q, Beeler Aaron B, Harris David A

发表日期：2024

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ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function

UBQLN2基因的ALS/FTD突变会通过功能丧失降低自噬体酸化，从而阻碍自噬。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1917371117

Wu, Josephine J; Cai, Ashley; Greenslade, Jessie E; Higgins, Nicole R; Fan, Cong; Le, Nhat T T; Tatman, Micaela; Whiteley, Alexandra M; Prado, Miguel A; Dieriks, Birger V; Curtis, Maurice A; Shaw, Christopher E; Siddique, Teepu; Faull, Richard L M; Scotter, Emma L; Finley, Daniel; Monteiro, Mervyn J

发表日期：2020

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Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations

表达与 ALS-FTD 相关的 UBQLN2 突变的小鼠出现运动神经元疾病、TDP-43 病理和记忆缺陷

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1608432113

Le, Nhat T T; Chang, Lydia; Kovlyagina, Irina; Georgiou, Polymnia; Safren, Nathaniel; Braunstein, Kerstin E; Kvarta, Mark D; Van Dyke, Adam M; LeGates, Tara A; Philips, Thomas; Morrison, Brett M; Thompson, Scott M; Puche, Adam C; Gould, Todd D; Rothstein, Jeffrey D; Wong, Philip C; Monteiro, Mervyn J

发表日期：2016

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