日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

转录因子Foxa1及其靶基因的过表达可缓解中国仓鼠卵巢细胞中治疗性蛋白的生产瓶颈。

Berger, Audrey; Le Fourn, Valérie; Masternak, Jacqueline; Regamey, Alexandre; Bodenmann, Iris; Girod, Pierre-Alain; Mermod, Nicolas

Genome-wide analysis of single nucleotide variants allows for robust and accurate assessment of clonal derivation in cell lines used to produce biologics

对单核苷酸变异进行全基因组分析,可以对用于生产生物制剂的细胞系中的克隆衍生进行稳健而准确的评估。

Kuhn, Alexandre; Le Fourn, Valérie; Fisch, Igor; Mermod, Nicolas

Influence of cytoskeleton organization on recombinant protein expression by CHO cells

细胞骨架组织对 CHO 细胞重组蛋白表达的影响

Lucille Pourcel, Flavien Buron, Ghislaine Arib, Valérie Le Fourn, Alexandre Regamey, Iris Bodenmann, Pierre-Alain Girod, Nicolas Mermod

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

来自 CHO 细胞系的非切割依赖性 HIV-1 三聚体可诱导产生强效的自体二级中和抗体

Bale, Shridhar; Martiné, Alexandra; Wilson, Richard; Behrens, Anna-Janina; Le Fourn, Valérie; de Val, Natalia; Sharma, Shailendra K; Tran, Karen; Torres, Jonathan L; Girod, Pierre-Alain; Ward, Andrew B; Crispin, Max; Wyatt, Richard T

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

MAR 介导的转基因整合到允许的染色质中并通过重组途径工程增加表达

Kaja Kostyrko, Samuel Neuenschwander, Thomas Junier, Alexandre Regamey, Christian Iseli, Emanuel Schmid-Siegert, Sandra Bosshard, Stefano Majocchi, Valérie Le Fourn, Pierre-Alain Girod, Ioannis Xenarios, Nicolas Mermod

Large protein complexes retained in the ER are dislocated by non-COPII vesicles and degraded by selective autophagy

内质网中滞留的大型蛋白质复合物被非 COPII 囊泡移位,并通过选择性自噬降解

Valerie Le Fourn, Sujin Park, Insook Jang, Katarina Gaplovska-Kysela, Bruno Guhl, Yangsin Lee, Jin Won Cho, Christian Zuber, Jürgen Roth

MAR elements and transposons for improved transgene integration and expression

MAR 元件和转座子用于改善转基因整合和表达

Déborah Ley, Niamh Harraghy, Valérie Le Fourn, Solenne Bire, Pierre-Alain Girod, Alexandre Regamey, Florence Rouleux-Bonnin, Yves Bigot, Nicolas Mermod

Study design and quality of reporting of randomized controlled trials of chronic idiopathic or autoimmune urticaria: review

慢性特发性或自身免疫性荨麻疹随机对照试验的研究设计和报告质量:综述

Le Fourn, Elodie; Giraudeau, Bruno; Chosidow, Olivier; Doutre, Marie-Sylvie; Lorette, Gérard

Basal autophagy is involved in the degradation of the ERAD component EDEM1

基础自噬参与 ERAD 成分 EDEM1 的降解

V Le Fourn, K Gaplovska-Kysela, B Guhl, R Santimaria, C Zuber, J Roth

Protein quality control: the who's who, the where's and therapeutic escapes

蛋白质质量控制:涉及人员、地点及治疗途径

Roth, Jürgen; Yam, Gary Hin-Fai; Fan, Jingyu; Hirano, Kiyoko; Gaplovska-Kysela, Katarina; Le Fourn, Valerie; Guhl, Bruno; Santimaria, Roger; Torossi, Tania; Ziak, Martin; Zuber, Christian