日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients

一项包含675,680名住院患者样本的多中心、多种族全基因组关联研究荟萃分析,旨在探讨功能性癫痫发作障碍的关联性。

Goleva, Slavina B; Leu, Costin; Anne Feng, Yen-Chen; Burstein, David; Venkatesh, Sanan; Birnbaum, Rebecca; Rajagopal, Veera M; Straub, Peter; Christensen, Jakob; Bautista, Jocelyn F; Busch, Robyn M; Najm, Imad M; Grove, Jakob; Børglum, Anders D; Voloudakis, Georgios; Roussos, Panos; Smoller, Jordan; Lal, Dennis; Davis, Lea K

Polygenic and developmental profiles of autism differ by age at diagnosis

自闭症的多基因和发育特征因诊断年龄而异。

Zhang, Xinhe; Grove, Jakob; Gu, Yuanjun; Buus, Cornelia K; Nielsen, Lea K; Neufeld, Sharon A S; Koko, Mahmoud; Malawsky, Daniel S; Wade, Emma M; Verhoef, Ellen; Gui, Anna; Hegemann, Laura; Geschwind, Daniel H; Wray, Naomi R; Havdahl, Alexandra; Ronald, Angelica; St Pourcain, Beate; Robinson, Elise B; Bourgeron, Thomas; Baron-Cohen, Simon; Børglum, Anders D; Martin, Hilary C; Warrier, Varun

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

全基因组分析确定了30个与强迫症相关的基因位点

Strom, Nora I; Gerring, Zachary F; Galimberti, Marco; Yu, Dongmei; Halvorsen, Matthew W; Abdellaoui, Abdel; Rodriguez-Fontenla, Cristina; Sealock, Julia M; Bigdeli, Tim; Coleman, Jonathan R; Mahjani, Behrang; Thorp, Jackson G; Bey, Katharina; Burton, Christie L; Luykx, Jurjen J; Zai, Gwyneth; Alemany, Silvia; Andre, Christine; Askland, Kathleen D; Bäckman, Julia; Banaj, Nerisa; Barlassina, Cristina; Nissen, Judith Becker; Bienvenu, O Joseph; Black, Donald; Bloch, Michael H; Børte, Sigrid; Bosch, Rosa; Breen, Michael; Brennan, Brian P; Brentani, Helena; Buxbaum, Joseph D; Bybjerg-Grauholm, Jonas; Byrne, Enda M; Cabana-Dominguez, Judit; Camarena, Beatriz; Camarena, Adrian; Cappi, Carolina; Carracedo, Angel; Casas, Miguel; Cavallini, Maria Cristina; Ciullo, Valentina; Cook, Edwin H; Crosby, Jesse; Cullen, Bernadette A; De Schipper, Elles J; Delorme, Richard; Djurovic, Srdjan; Elias, Jason A; Estivill, Xavier; Falkenstein, Martha J; Fundin, Bengt T; Garner, Lauryn; Gironda, Christina; Goes, Fernando S; Grados, Marco A; Grove, Jakob; Guo, Wei; Haavik, Jan; Hagen, Kristen; Harrington, Kelly; Havdahl, Alexandra; Höffler, Kira D; Hounie, Ana G; Hucks, Donald; Hultman, Christina; Janecka, Magdalena; Jenike, Eric; Karlsson, Elinor K; Kelley, Kara; Klawohn, Julia; Krasnow, Janice E; Krebs, Kristi; Lange, Christoph; Lanzagorta, Nuria; Levey, Daniel; Lindblad-Toh, Kerstin; Macciardi, Fabio; Maher, Brion; Mathes, Brittany; McArthur, Evonne; McGregor, Nathaniel; McLaughlin, Nicole C; Meier, Sandra; Miguel, Euripedes C; Mulhern, Maureen; Nestadt, Paul S; Nurmi, Erika L; O'Connell, Kevin S; Osiecki, Lisa; Ousdal, Olga Therese; Palviainen, Teemu; Pedersen, Nancy L; Piras, Fabrizio; Piras, Federica; Potluri, Sriramya; Rabionet, Raquel; Ramirez, Alfredo; Rauch, Scott; Reichenberg, Abraham; Riddle, Mark A; Ripke, Stephan; Rosário, Maria C; Sampaio, Aline S; Schiele, Miriam A; Skogholt, Anne Heidi; Sloofman, Laura G; Smit, Jan; Artigas, María Soler; Thomas, Laurent F; Tifft, Eric; Vallada, Homero; van Kirk, Nathanial; Veenstra-VanderWeele, Jeremy; Vulink, Nienke N; Walker, Christopher P; Wang, Ying; Wendland, Jens R; Winsvold, Bendik S; Yao, Yin; Zhou, Hang; Agrawal, Arpana; Alonso, Pino; Berberich, Götz; Bucholz, Kathleen K; Bulik, Cynthia M; Cath, Danielle; Denys, Damiaan; Eapen, Valsamma; Edenberg, Howard; Falkai, Peter; Fernandez, Thomas V; Fyer, Abby J; Gaziano, J M; Geller, Dan A; Grabe, Hans J; Greenberg, Benjamin D; Hanna, Gregory L; Hickie, Ian B; Hougaard, David M; Kathmann, Norbert; Kennedy, James; Lai, Dongbing; Landén, Mikael; Hellard, Stéphanie Le; Leboyer, Marion; Lochner, Christine; McCracken, James T; Medland, Sarah E; Mortensen, Preben B; Neale, Benjamin M; Nicolini, Humberto; Nordentoft, Merete; Pato, Michele; Pato, Carlos; Pauls, David L; Piacentini, John; Pittenger, Christopher; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Rasmussen, Steven A; Richter, Margaret A; Rosenberg, David R; Ruhrmann, Stephan; Samuels, Jack F; Sandin, Sven; Sandor, Paul; Spalletta, Gianfranco; Stein, Dan J; Stewart, S Evelyn; Storch, Eric A; Stranger, Barbara E; Turiel, Maurizio; Werge, Thomas; Andreassen, Ole A; Børglum, Anders D; Walitza, Susanne; Hveem, Kristian; Hansen, Bjarne K; Rück, Christian; Martin, Nicholas G; Milani, Lili; Mors, Ole; Reichborn-Kjennerud, Ted; Ribasés, Marta; Kvale, Gerd; Mataix-Cols, David; Domschke, Katharina; Grünblatt, Edna; Wagner, Michael; Zwart, John-Anker; Breen, Gerome; Nestadt, Gerald; Kaprio, Jaakko; Arnold, Paul D; Grice, Dorothy E; Knowles, James A; Ask, Helga; Verweij, Karin J; Davis, Lea K; Smit, Dirk J; Crowley, James J; Scharf, Jeremiah M; Stein, Murray B; Gelernter, Joel; Mathews, Carol A; Derks, Eske M; Mattheisen, Manuel

The Psychiatric Genomics Consortium: discoveries and directions

精神病基因组学联盟:发现与方向

Agrawal, Arpana; Bulik, Cynthia M; Abebe, Dawit Shawel; Andreassen, Ole A; Atkinson, Elizabeth G; Choi, Karmel W; Corvin, Aiden; Davies, Helena L; Davis, Lea K; Docherty, Anna R; Edenberg, Howard J; Franke, Barbara; Gelernter, Joel; Giusti-Rodríguez, Paola; Hettema, John M; Hjerling-Leffler, Jens; Huang, Hailiang; Johnson, Emma C; Lewis, Cathryn M; Lu, Yi; Lynall, Mary-Ellen; Martin, Joanna; McIntosh, Andrew M; Montalvo-Ortiz, Janitza L; Mullins, Niamh; Nievergelt, Caroline M; O'Connell, Kevin S; O'Donovan, Michael C; Okewole, Adeniran; Peterson, Roseann E; Posthuma, Danielle; Sebat, Jonathan; Smoller, Jordan W; Sud, Reeteka; Viswanath, Biju; Walters, James T R; Won, Hyejung; Wray, Naomi R; Sullivan, Patrick F

Sexual Trauma, Polygenic Scores, and Mental Health Diagnoses and Outcomes

性创伤、多基因评分、心理健康诊断和结果

Lake, Allison M; Zhou, Yu; Wang, Bo; Actkins, Ky'Era V; Zhang, Yingzhe; Shelley, John P; Rajamani, Anindita; Steigman, Michael; Kennedy, Chris J; Smoller, Jordan W; Choi, Karmel W; Khankari, Nikhil K; Davis, Lea K

Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin.

氨通过减少成熟穿孔素来抑制自然杀伤细胞和T细胞的抗肿瘤活性

Domagala Joanna, Grzywa Tomasz M, Baranowska Iwona, Justyniarska Magdalena, Tannir Ryan, Graczyk-Jarzynka Agnieszka, Kusowska Aleksandra, Lecka Maria, Poreba Marcin, Fidyt Klaudyna, Marhelava Katsiaryna, Pilch Zofia, Picard Lea K, Wegierski Tomasz, Jastrzebski Kamil, Krawczyk Marta, Klopotowska Marta, Granica Monika, Urlaub Doris, Hajduk Szymon, Neeser Alexandra, Moros Spencer, Kozlowski Pawel, Bobrowicz Malgorzata, Miaczynska Marta, Ma Leyuan, Watzl Carsten, Winiarska Magdalena

An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems

酶级联反应使得在复杂的生物系统中实现灵敏且特异的邻近标记蛋白质组学成为可能。

Tommy J Sroka ,Lea K Sanwald # ,Avishek Prasai # ,Josefine Hoeren ,Valentina Trivigno ,Valerie Chaumet ,Louisa M Krauß ,Damian Weber ,Daniela Yildiz ,Karina von der Malsburg ,Peter Walentek ,Per Haberkant ,Bianca Schrul ,Kerstin Feistel ,David U Mick

Predictors of Flares and Disease Severity in Patients With Atopic Dermatitis Using Machine Learning

利用机器学习预测特应性皮炎患者的病情发作和严重程度

Nielsen, Mia-Louise; Nymand, Lea K; Pena, Arnau Domenech; Du Jardin, Kristian G; Kasujee, Ismail; Thomsen, Simon F; Thein, David

Clinical Characteristics associated with functional seizures in individuals with psychosis

精神病患者功能性癫痫发作的临床特征

Lake, Allison M; Reddy, India A; Havranek, Robert; Davis, Lea K; Fox, Jonah