日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep model

在非近交绵羊模型中,性别特异性的多代表观遗传反应对真实世界化学混合物暴露的影响

Hargreaves, Oliver G; Kwong, Wing Yee; Warry, Andrew; Tutt, Desmond Ar; Padmanabhan, Vasantha; Evans, Neil P; Lea, Richard G; Bellingham, Michelle; Sinclair, Kevin D

In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.

子宫内接触真实环境中的化学物质会扰乱青春期前和成年公羊下丘脑-垂体-性腺轴内的基因表达

Ghasemzadeh Hasankolaei Mohammad, Evans Neil P, Elcombe Chris S, Lea Richard G, Sinclair Kevin D, Padmanabhan Vasantha, Bellingham Michelle

Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep

发育编程:产前暴露于真实环境化学物质混合物对绵羊肝功能和转录组的性别特异性影响

Thangaraj, Soundara Viveka; Bellingham, Michelle; Lea, Richard; Evans, Neil; Sinclair, Kevin; Padmanabhan, Vasantha

Developmental programming: mechanisms of early exposure to real-life chemicals in biosolids on offspring ovarian dynamics†.

发育编程:早期接触生物固体中真实化学物质对后代卵巢动态的影响机制”

Zhou Yiran, Halloran Katherine M, Bellingham Michelle, Lea Richard G, Evans Neil P, Sinclair Kevin D, Smith Peter, Padmanabhan Vasantha

MON-169 Developmental Programming: Adverse Effects of Preconceptional and Gestational Exposure to a Real-Life Environmental Chemical Mixture via Biosolids on Oocyte Quality in Prepubertal Sheep

MON-169 发育编程:通过生物固体途径在受孕前和妊娠期接触真实环境化学混合物对青春期前绵羊卵母细胞质量的不良影响

Inbar, Ehud; Samantray, Ishaan; Alford, Robert T; Harrell, Robert A; Jennings, Grace; Pascini, Tales V; Wai, Tint T; Eappen, Abraham; Hoffman, Stephen L; Billingsley, Peter F; Zhou, Yiran; Bellingham, Michelle; Lea, Richard G; Evans, Neil P; Sinclair, Kevin D; Padmanabhan, Vasantha

Preconceptional and in utero exposure of sheep to a real-life environmental chemical mixture disrupts key markers of energy metabolism in male offspring

绵羊在受孕前和子宫内暴露于真实环境中的化学混合物会扰乱雄性后代能量代谢的关键指标。

Ghasemzadeh-Hasankolaei, Mohammad; Elcombe, Chris S; Powls, Samantha; Lea, Richard G; Sinclair, Kevin D; Padmanabhan, Vasantha; Evans, Neil P; Bellingham, Michelle

Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep

绵羊在孕前和妊娠期暴露于真实环境化学混合物(生物固体)对其后代生长动态和青春期发育的性别二态性影响

Evans, Neil P; Bellingham, Michelle; Elcombe, Christopher S; Ghasemzadeh-Hasankolaei, Mohammad; Lea, Richard G; Sinclair, Kevin D; Padmanabhan, Vasantha

Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication

非细胞毒性水平的 Thapsigargin 可诱导强效宿主抗病毒反应,从而阻断甲型流感病毒复制

Leah V Goulding, Jiayun Yang, Zhimin Jiang, Hongyu Zhang, Daniel Lea, Richard D Emes, Tania Dottorini, Juan Pu, Jinhua Liu, Kin-Chow Chang

Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

Kauniolide 合酶是一种具有不寻常羟基化和环化消除活性的 P450

Qing Liu, Arman Beyraghdar Kashkooli, David Manzano, Irini Pateraki, Lea Richard, Pim Kolkman, Maria Fátima Lucas, Victor Guallar, Ric C H de Vos, Maurice C R Franssen, Alexander van der Krol, Harro Bouwmeester1

DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status

母体围孕期B族维生素和蛋氨酸水平决定子代DNA甲基化、胰岛素抵抗和血压水平

Sinclair, Kevin D; Allegrucci, Cinzia; Singh, Ravinder; Gardner, David S; Sebastian, Sonia; Bispham, Jayson; Thurston, Alexandra; Huntley, John F; Rees, William D; Maloney, Christopher A; Lea, Richard G; Craigon, Jim; McEvoy, Tom G; Young, Lorraine E