日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

基因工程改造的人类类器官模型揭示了早期胰腺导管腺癌转化过程中谱系可塑性的独特遗传和表观遗传屏障

期刊:
影响因子:
doi:10.64898/2026.03.09.710586
Zhang, Xian; Wong, Wilfred; Cho, Hyein S; Yang, Dapeng; Dixon, Gary; Luo, Renhe; Liu, Dingyu; Torre, Denis; Umeda, Shigeaki; González, Federico; Askan, Gokce; Yavas, Aslihan; Damodaran, Jeyaram Ravichandran; Rickert, Robert W; Kappagantula, Rajya; Pan, Fong Cheng; Aveson, Victoria G; Grimont, Adrien; Pulecio, Julian; Kaplan, Samuel J; Pan, Heng; Leach, Steven D; Iacobuzio-Donahue, Christine A; Chandwani, Rohit; Leslie, Christina S; Huangfu, Danwei
Human
3D/类器官
表观遗传
肿瘤
肿瘤免疫
发表日期：2026
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Lifetime water arsenic, genetic susceptibility, and bladder cancer in the New England Bladder Cancer Study

新英格兰膀胱癌研究中终生饮用水砷、遗传易感性和膀胱癌的关系

期刊:JNCI Cancer Spectrum
影响因子:4.1
doi:10.1093/jncics/pkaf064
Pomares-Millan, Hugo; Koutros, Stella; Baris, Dalsu; Schwenn, Molly; Johnson, Alison; Rothman, Nathaniel; Silverman, Debra T; Leach, Steven D; Karagas, Margaret R; Passarelli, Michael N
肿瘤
肿瘤免疫
膀胱癌
发表日期：2025
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Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

斑马鱼幼体切片的空间紧凑排列及其在空间转录组分析中的应用

期刊:Jove-Journal of Visualized Experiments
影响因子:1
doi:10.3791/67683
Buford, Jacob; Wilkins, Owen; Kolling, Fred 4th; Leach, Steven D; Morhardt, Duncan
发表日期：2025
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Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

分子动力学驱动胰腺肿瘤发生过程中KRAS突变体表型分化

期刊:
影响因子:
doi:10.1101/2025.05.28.656689
Grimont, Adrien; Falvo, David J; Sisso, Whitney J; Zumbo, Paul; Chan, Christopher W; Santos, Francisco; Pan, Grace; Cleveland, Megan; Yaron, Tomer M; Osterhoudt, Alexa; Meng, Yinuo; Zafra, Maria Paz; Fall, William B; Rendeiro, Andre F; Hissong, Erika; Yantiss, Rhonda K; Betel, Doron; Magnuson, Mark A; Leach, Steven D; Rustgi, Anil K; Dow, Lukas E; Chandwani, Rohit
肿瘤
RAS
肿瘤免疫
发表日期：2025
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Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer

不确定的开端：腺泡细胞和导管细胞在胰腺癌发展中的可塑性

期刊:Cellular and Molecular Gastroenterology and Hepatology
影响因子:7.4
doi:10.1016/j.jcmgh.2021.07.014
Grimont, Adrien; Leach, Steven D; Chandwani, Rohit
胰腺癌
肿瘤
肿瘤免疫
细胞生物学
发表日期：2022
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Prioritizing Measures That Matter Within a Person-Centered Oncology Learning Health System

在以人为本的肿瘤学习型医疗系统中，优先考虑那些真正重要的措施

期刊:JNCI Cancer Spectrum
影响因子:4.1
doi:10.1093/jncics/pkac037
Van Citters, Aricca D; Kennedy, Alice M; Kirkland, Kathryn B; Dragnev, Konstantin H; Leach, Steven D; Buus-Frank, Madge E; Malcolm, Elissa F; Holthoff, Megan M; Holmes, Anne B; Nelson, Eugene C; Reeves, Susan A; Tosteson, Anna N A
肿瘤
肿瘤免疫
发表日期：2022
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Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies

胰腺癌驱动突变可通过远端选择性RNA剪接依赖性进行靶向治疗。

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.27901
Kawalerski, Ryan R; Leach, Steven D; Escobar-Hoyos, Luisa F
胰腺癌
肿瘤
肿瘤免疫
发表日期：2021
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ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.

ID1介导胰腺癌细胞逃避TGFβ肿瘤抑制

期刊:Cancer Discovery
影响因子:33.3
doi:10.1158/2159-8290.CD-19-0529
Huang Yun-Han, Hu Jing, Chen Fei, Lecomte Nicolas, Basnet Harihar, David Charles J, Witkin Matthew D, Allen Peter J, Leach Steven D, Hollmann Travis J, Iacobuzio-Donahue Christine A, Massagué Joan
肿瘤
胰腺癌
发表日期：2020
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Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma

对癌症药物进行无偏倚的体内临床前评估，可确定治疗胰腺腺癌的有效疗法。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1920240117
Grbovic-Huezo, Olivera; Pitter, Kenneth L; Lecomte, Nicolas; Saglimbeni, Joseph; Askan, Gokce; Holm, Matilda; Melchor, Jerry P; Chandwani, Rohit; Joshi, Suhasini; Haglund, Caj; Iacobuzio-Donahue, Christine A; Chiosis, Gabriela; Tammela, Tuomas; Leach, Steven D
肿瘤
肿瘤免疫
发表日期：2020
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Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter?

年轻患者与老年患者胰腺腺癌的基因组图谱：年龄重要吗？

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-18-3042
Ben-Aharon, Irit; Elkabets, Moshe; Pelossof, Raphael; Yu, Kenneth H; Iacubuzio-Donahue, Christine A; Leach, Steven D; Lowery, Maeve A; Goodman, Karyn A; O'Reilly, Eileen M
肿瘤
肿瘤免疫
发表日期：2019
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