日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

通过体内糖基转移酶交换对庆大霉素进行糖基多样化,可以创造出具有高效活性和低耳毒性的新型杂合氨基糖苷类抗生素。

Jian, Xinyun; Wang, Cheng; Wu, Shijuan; Sun, Guo; Huang, Chuan; Qiu, Chengbing; Liu, Yuanzheng; Leadlay, Peter F; Liu, Dong; Deng, Zixin; Zhou, Fuling; Sun, Yuhui

Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis

庆大霉素生物合成中GenB2异构酶活性的结构和功能基础

Oliveira, Gabriel S de; Dos S Bury, Priscila; Huang, Fanglu; Li, Yuan; Araújo, Natália C de; Zhou, Jiahai; Sun, Yuhui; Leeper, Finian J; Leadlay, Peter F; Dias, Marcio V B

Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition

深入了解 azalomycin F 装配线有助于进化引导的聚酮化合物合酶工程和模块间识别的识别

Guifa Zhai #, Yan Zhu #, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun

Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase

含有3-羟基苯甲酸酯部分且具有选择性抗癌活性的缩肽的生物合成涉及一种分支酸酶。

Shen, Yaoyao; Sun, Fan; Zhang, Liu; Cheng, Yijia; Zhu, Hongrui; Wang, Shu-Ping; Jiao, Wei-Hua; Leadlay, Peter F; Zhou, Yongjun; Lin, Hou-Wen

The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic

四氢马杜林(SF2487/A80577)是一种聚醚四酮酸酯类抗生素,其生物合成途径如下:

Little, Rory F; Samborskyy, Markiyan; Leadlay, Peter F

The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety

奥沙霉素(一种带有螺缩醛部分的环状聚酮化合物)的生物合成途径

Bilyk, Oksana; Samborskyy, Markiyan; Leadlay, Peter F

An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain

阿扎霉素F聚酮合酶中的一个迭代模块包含一个可切换的烯酰还原酶结构域

Xu, Wei; Zhai, Guifa; Liu, Yuanzhen; Li, Yuan; Shi, Yanrong; Hong, Kui; Hong, Hui; Leadlay, Peter F; Deng, Zixin; Sun, Yuhui

An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics

脒基水解酶为氨基边缘内酯类抗生素的生物合成提供了缺失的一环

Hong, Hui; Samborskyy, Markiyan; Lindner, Frederick; Leadlay, Peter F

A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis

利用基因组学方法解析硫代四酮类抗生素生物合成机制

Tao, W; Yurkovich, M E; Wen, S; Lebe, K E; Samborskyy, M; Liu, Y; Yang, A; Liu, Y; Ju, Y; Deng, Z; Tosin, M; Sun, Y; Leadlay, P F

An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35

一种高效构建雷帕霉素产生菌伊朗链霉菌HM 35基因缺失突变体的方法

Netzker, Tina; Schroeckh, Volker; Gregory, Matthew A; Flak, Michal; Krespach, Mario K C; Leadlay, Peter F; Brakhage, Axel A