Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity
通过体内糖基转移酶交换对庆大霉素进行糖基多样化,可以创造出具有高效活性和低耳毒性的新型杂合氨基糖苷类抗生素。
期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2024.04.030
Jian, Xinyun; Wang, Cheng; Wu, Shijuan; Sun, Guo; Huang, Chuan; Qiu, Chengbing; Liu, Yuanzheng; Leadlay, Peter F; Liu, Dong; Deng, Zixin; Zhou, Fuling; Sun, Yuhui