日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase II Clinical Trial and Preclinical Evaluation of a Novel CD47 Blockade Combination in Refractory Microsatellite-Stable Metastatic Colorectal Cancer

新型CD47阻断联合疗法治疗难治性微卫星稳定型转移性结直肠癌的II期临床试验和临床前评估

Lentz, Robert W; Lang, Julie; Pitts, Todd M; Blatchford, Patrick; Hu, Junxiao; Jordan, Kimberly R; Van Bokhoven, Adrie; Bagby, Stacey M; Dominguez, Adrian T A; Binns, Cameron A; Robinson, Hannah R; Balmaceda, Nicole; Baiyee, Emily; Leal, Alexis D; Kim, Sunnie S; Davis, S Lindsey; Lieu, Christopher H; Wadlow, Raymond C; Spencer, Kristen; Scott, Aaron J; Boland, Patrick M; Hochster, Howard S; Messersmith, Wells A

A Phase II Study of Potentiation of Pembrolizumab with Binimetinib and Bevacizumab in Refractory Microsatellite-Stable Colorectal Cancer

一项评估帕博利珠单抗联合比美替尼和贝伐珠单抗增强治疗难治性微卫星稳定型结直肠癌的II期研究

Lentz, Robert W; Friedrich, Tyler J; Blatchford, Patrick J; Jordan, Kimberly R; Pitts, Todd M; Robinson, Hannah R; Davis, S Lindsey; Kim, Sunnie S; Leal, Alexis D; Lee, Mathew R; Waring, Meredith R N; Martin, Anne C; Dominguez, Adrian T A; Bagby, Stacey M; Hartman, Sarah J; Eckhardt, S Gail; Messersmith, Wells A; Lieu, Christopher H

Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors

阑尾神经内分泌肿瘤患者淋巴结疾病相关的病理特征

Rodriguez Franco, Salvador; Ghaffar, Sumaya Abdul; Jin, Ying; Weiss, Reed; Hamermesh, Mona; Khomiak, Andrii; Sugawara, Toshitaka; Franklin, Oskar; Leal, Alexis D; Lieu, Christopher H; Schulick, Richard D; Del Chiaro, Marco; Ahrendt, Steven; McCarter, Martin D; Gleisner, Ana L

Relacorilant plus nab-paclitaxel for the treatment of metastatic pancreatic ductal adenocarcinoma: results from the open-label RELIANT study

瑞拉可兰联合白蛋白紫杉醇治疗转移性胰腺导管腺癌:来自开放标签 RELIANT 研究的结果

Borazanci, Erkut H; Bahary, Nathan; Chung, Vincent; Huyck, Timothy K; Kio, Ebenezer A; Chiorean, Elena Gabriela; Skeel, Roland T; Alese, Olatunji B; Cardin, Dana B; Fountzilas, Christos; Hanna, Wahid T; Leal, Alexis D; Lee, Valerie; Noonan, Anne M; Philip, Philip A; Wainberg, Zev A; Pashova, Hristina; Mann, Grace; Oberstein, Paul E

Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).

利用胰腺肿瘤类器官库(PTOL)研究Wnt信号通路作为胰腺导管腺癌(PDAC)治疗靶点的作用

Hawkins Hayley J, Yacob Betelehem W, Brown Monica E, Goldstein Brandon R, Arcaroli John J, Bagby Stacey M, Hartman Sarah J, Macbeth Morgan, Goodspeed Andrew, Danhorn Thomas, Lentz Robert W, Lieu Christopher H, Leal Alexis D, Messersmith Wells A, Dempsey Peter J, Pitts Todd M

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment.

胰腺导管腺癌细胞通过调节 NLRP3 激活来产生耐受性微环境

Amo-Aparicio Jesus, Dominguez Adrian, Atif Shaikh M, Dinarello Alberto, Azam Tania, Alula Kibrom M, Piper Miles, Lieu Christopher H, Lentz Robert W, Leal Alexis D, Bagby Stacey M, Messersmith Wells A, Karam Sana D, Dinarello Charles A, Pitts Todd M, Marchetti Carlo

Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors

一项旨在确定自体外周血单核细胞经修饰可呈递 HPV16 抗原 (SQZ-PBMC-HPV) 在 HLA-A*02+ HPV16+ 实体瘤患者中的安全性和剂量的 1 期研究

Jimeno, Antonio; Baranda, Joaquina; Iams, Wade T; Park, Jong Chul; Mita, Monica; Gordon, Michael S; Taylor, Matthew; Dhani, Neesha; Leal, Alexis D; Neupane, Prakash; Eng, Cathy; Yeku, Oladapo; Mita, Alain; Moser, Justin C; Butler, Marcus; Loughhead, Scott M; Jennings, Julia; Miselis, Nathan R; Ji, Rui-Ru; Nair, Nitya; Kornacker, Martin; Zwirtes, Ricardo F; Bernstein, Howard; Sharei, Armon

A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C

一项针对表达鸟苷酸环化酶C的晚期胃肠道癌症患者的TAK-164(一种抗体药物偶联物)的I期首次人体研究。

Kim, Richard; Leal, Alexis D; Parikh, Aparna; Ryan, David P; Wang, Shining; Bahamon, Brittany; Gupta, Neeraj; Moss, Aaron; Pye, Joanna; Miao, Harry; Inguilizian, Haig; Cleary, James M

Correction to: A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C

更正:一项针对表达鸟苷酸环化酶C的晚期胃肠道癌症患者的TAK-164(一种抗体药物偶联物)的I期首次人体研究

Kim, Richard; Leal, Alexis D; Parikh, Aparna; Ryan, David P; Wang, Shining; Bahamon, Brittany; Gupta, Neeraj; Moss, Aaron; Pye, Joanna; Miao, Harry; Inguilizian, Haig; Cleary, James M

ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

ATM激酶抑制剂AZD0156联合伊立替康和5-氟尿嘧啶治疗结直肠癌的临床前模型

Davis, S Lindsey; Hartman, Sarah J; Bagby, Stacey M; Schlaepfer, Marina; Yacob, Betelehem W; Tse, Tonia; Simmons, Dennis M; Diamond, Jennifer R; Lieu, Christopher H; Leal, Alexis D; Cadogan, Elaine B; Hughes, Gareth D; Durant, Stephen T; Messersmith, Wells A; Pitts, Todd M