日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Conformational diversity in class C GPCR positive allosteric modulation.

C类GPCR正变构调节的构象多样性

Cannone Giuseppe, Berto Ludovic, Malhaire Fanny, Ferguson Gavin, Fouillen Aurelien, Balor Stéphanie, Font-Ingles Joan, Llebaria Amadeu, Goudet Cyril, Kotecha Abhay, K R Vinothkumar, Lebon Guillaume

Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.

利用第四代同步加速器上的微秒级 X 射线脉冲推进大分子结构测定

Orlans Julien, Rose Samuel L, Ferguson Gavin, Oscarsson Marcus, Homs Puron Alejandro, Beteva Antonia, Debionne Samuel, Theveneau Pascal, Coquelle Nicolas, Kieffer Jerome, Busca Paolo, Sinoir Jeremy, Armijo Victor, Lopez Marrero Marcos, Felisaz Franck, Papp Gergely, Gonzalez Herve, Caserotto Hugo, Dobias Fabien, Gigmes Jonathan, Lebon Guillaume, Basu Shibom, de Sanctis Daniele

Steering G protein activation by mGlu heterodimer

mGlu异二聚体调控G蛋白激活

Lebon, Guillaume

Inhibition of the angiotensin II type 2 receptor AT(2)R is a novel therapeutic strategy for glioblastoma.

抑制血管紧张素 II 2 型受体 AT(2)R 是治疗胶质母细胞瘤的一种新型治疗策略

Perryman Richard, Renziehausen Alexander, Shaye Hamidreza, Kostagianni Androniki D, Tsiailanis Antonis D, Thorne Thomas, Chatziathanasiadou Maria V, Sivolapenko Gregory B, El Mubarak Mohamed Ahmed, Han Gye Won, Zarzycka Barbara, Katritch Vsevolod, Lebon Guillaume, Lo Nigro Cristiana, Lattanzio Laura, Morse Sophie V, Choi James J, O'Neill Kevin, Kanaki Zoi, Klinakis Apostolos, Crook Tim, Cherezov Vadim, Tzakos Andreas G, Syed Nelofer

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone

具有镇痛作用的细菌毒素:Mycolactone 导致 DRG 神经元超极化

Ok-Ryul Song, Han-Byul Kim, Samuel Jouny, Isabelle Ricard, Alexandre Vandeputte, Nathalie Deboosere, Estelle Marion, Christophe J Queval, Pierre Lesport, Emmanuel Bourinet, Daniel Henrion, Seog Bae Oh, Guillaume Lebon, Guillaume Sandoz, Edouard Yeramian, Laurent Marsollier, Priscille Brodin7

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

A类GPCR的多种激活通路在G蛋白偶联区附近汇合。

Venkatakrishnan, A J; Deupi, Xavier; Lebon, Guillaume; Heydenreich, Franziska M; Flock, Tilman; Miljus, Tamara; Balaji, Santhanam; Bouvier, Michel; Veprintsev, Dmitry B; Tate, Christopher G; Schertler, Gebhard F X; Babu, M Madan

Pharmacology and structure of isolated conformations of the adenosine A₂A receptor define ligand efficacy

腺苷A₂A受体分离构象的药理学和结构决定了配体的效力

Bennett, Kirstie A; Tehan, Benjamin; Lebon, Guillaume; Tate, Christopher G; Weir, Malcolm; Marshall, Fiona H; Langmead, Christopher J

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

激动剂结合的腺苷A2A受体结构揭示了GPCR激活的共同特征

Lebon, Guillaume; Warne, Tony; Edwards, Patricia C; Bennett, Kirstie; Langmead, Christopher J; Leslie, Andrew G W; Tate, Christopher G

Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening.

Pi 取样:一种系统而灵活的初始大分子结晶筛选方法

Gorrec Fabrice, Palmer Colin M, Lebon Guillaume, Warne Tony