日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

14-3-3 蛋白对 Ataxin-1 的细胞质伴侣作用的结构研究

Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions

基于结构的混杂抑制剂向蛋白质-蛋白质相互作用选择性稳定剂的进化

Eline Sijbesma #, Emira Visser #, Kathrin Plitzko, Philipp Thiel, Lech-Gustav Milroy, Markus Kaiser, Luc Brunsveld, Christian Ottmann

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

基于配体的变构视黄酸受体相关孤儿受体γt(RORγt)反向激动剂的设计

Femke A Meijer, Richard G Doveston, Rens M J M de Vries, Gaël M Vos, Alex A A Vos, Seppe Leysen, Marcel Scheepstra, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld

Tetrazine- trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging

四嗪-反式-环辛烯化学在制备用于体内双模成像的自组装荧光和放射性纳米粒子中的应用

van Onzen, Arthur H A M; Rossin, Raffaella; Schenning, Albertus P H J; Nicolay, Klaas; Milroy, Lech-Gustav; Robillard, Marc S; Brunsveld, Luc

Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires

混合寡核苷酸/盘状超分子导线中的双输入调控和位置控制

Alemán García, Miguel Ángel; Magdalena Estirado, Eva; Milroy, Lech-Gustav; Brunsveld, Luc

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

通过两种不同结合模式发挥作用的杂合小分子肽对 14-3-3/Tau 的抑制作用

Andrei, Sebastian A; Meijer, Femke A; Neves, João Filipe; Brunsveld, Luc; Landrieu, Isabelle; Ottmann, Christian; Milroy, Lech-Gustav

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3

基于葫芦脲[8]和二聚体适配器蛋白14-3-3的二元二价超分子组装平台

de Vink, Pim J; Briels, Jeroen M; Schrader, Thomas; Milroy, Lech-Gustav; Brunsveld, Luc; Ottmann, Christian

Designed Spiroketal Protein Modulation

设计螺缩酮蛋白调节

Scheepstra, Marcel; Andrei, Sebastian A; Unver, M Yagiz; Hirsch, Anna K H; Leysen, Seppe; Ottmann, Christian; Brunsveld, Luc; Milroy, Lech-Gustav

Supramolecular Chemistry Targeting Proteins

超分子化学靶向蛋白质

van Dun, Sam; Ottmann, Christian; Milroy, Lech-Gustav; Brunsveld, Luc

Semisynthetic Bioluminescent Sensor Proteins for Direct Detection of Antibodies and Small Molecules in Solution

半合成生物发光传感蛋白用于直接检测溶液中的抗体和小分子

Remco Arts, Susann K J Ludwig, Benice C B van Gerven, Eva Magdalena Estirado, Lech-Gustav Milroy, Maarten Merkx