日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

3D-MINFLUX nanoscopy reveals distinct allosteric mechanisms for activation and modulation of PIEZO1 by Yoda1

3D-MINFLUX纳米显微镜揭示了Yoda1激活和调节PIEZO1的独特变构机制

Verkest, Clement; Roettger, Lucas; Zeitzschel, Nadja; Lechner, Stefan G

Cluster nanoarchitecture and structural diversity of PIEZO1 at rest and during activation in intact cells

完整细胞中静息和激活状态下PIEZO1簇的纳米结构和结构多样性

Verkest, Clement; Roettger, Lucas; Zeitzschel, Nadja; Hall, James; Sánchez-Carranza, Oscar; Huang, Angela Tzu-Lun; Lewin, Gary R; Lechner, Stefan G

The activation thresholds and inactivation kinetics of poking-evoked PIEZO1 and PIEZO2 currents are sensitive to subtle variations in mechanical stimulation parameters

戳刺诱发的PIEZO1和PIEZO2电流的激活阈值和失活动力学对机械刺激参数的细微变化非常敏感。

Zeitzschel, Nadja; Lechner, Stefan G

PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2

PKA介导机械门控离子通道PIEZO2的模式特异性调节

Schaefer, Irina; Verkest, Clement; Vespermann, Lucas; Mair, Thomas; Voß, Hannah; Zeitzschel, Nadja; Lechner, Stefan G

Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2

固有无序的细胞内结构域控制着机械门控离子通道PIEZO2的关键特征。

Verkest, Clement; Schaefer, Irina; Nees, Timo A; Wang, Na; Jegelka, Juri M; Taberner, Francisco J; Lechner, Stefan G

TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors

耐TTX钠通道在功能上将沉默型和多模态C型伤害感受器区分开来

Jonas, Robin; Prato, Vincenzo; Lechner, Stefan G; Groen, Gerbrand; Obreja, Otilia; Werland, Fiona; Rukwied, Roman; Klusch, Andreas; Petersen, Marlen; Carr, Richard W; Schmelz, Martin

Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors.

对机械不敏感的“沉默”伤害感受器进行功能和分子表征

Prato Vincenzo, Taberner Francisco J, Hockley James R F, Callejo Gerard, Arcourt Alice, Tazir Bassim, Hammer Leonie, Schad Paulina, Heppenstall Paul A, Smith Ewan S, Lechner Stefan G

A genetic basis for mechanosensory traits in humans

人类机械感觉特征的遗传基础

Frenzel, Henning; Bohlender, Jörg; Pinsker, Katrin; Wohlleben, Bärbel; Tank, Jens; Lechner, Stefan G; Schiska, Daniela; Jaijo, Teresa; Rüschendorf, Franz; Saar, Kathrin; Jordan, Jens; Millán, José M; Gross, Manfred; Lewin, Gary R

The transcription factor c-Maf in sensory neuron development

感觉神经元发育中的转录因子c-Maf

Wende, Hagen; Lechner, Stefan G; Birchmeier, Carmen

Sensory transduction, the gateway to perception: mechanisms and pathology

感觉转导,通往知觉的门户:机制与病理

Lechner, Stefan G; Siemens, Jan