日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineering a Modular PapMV Nanoparticle Vaccine: Comparative Efficacy of a Covalent and a Non-Covalent N-Antigen Vaccine Against Emerging SARS-CoV-2 Variants

模块化PapMV纳米颗粒疫苗的工程设计:共价和非共价N抗原疫苗对抗新出现的SARS-CoV-2变种的疗效比较

Blanchette, Léa-J; Bolduc, Marilène; Woldemariam, Tekeleselassie; Yousefi, Mitra; Rabezanahary, Henintsoa; Olivera-Ugarte, Santa-M; Garneau, Caroline; Angers, Myriam; Shi, Rong; Flamand, Louis; Baz, Mariana; Vidal, Silvia; Falzarano, Darryl; Lemay, Jean-François; Leclerc, Denis

Systemic administration of a viral nanoparticle neoadjuvant prevents lung metastasis development through emergency myelopoiesis

全身性施用病毒纳米颗粒新佐剂可通过紧急髓系造血作用预防肺转移的发生

Bourguignon, Léa; Hétu-Arbour, Roxann; Charpentier, Tania; Bolduc, Marilène; Leclerc, Denis; Heinonen, Krista M; Lamarre, Alain

A nanoparticle-based COVID-19 vaccine candidate elicits broad neutralizing antibodies and protects against SARS-CoV-2 infection

一种基于纳米颗粒的新冠病毒候选疫苗可诱导产生广谱中和抗体,并能预防SARS-CoV-2感染。

Olivera-Ugarte, Santa-Mariela; Bolduc, Marilène; Laliberté-Gagné, Marie-Ève; Blanchette, Léa-Jeanne; Garneau, Caroline; Fillion, Maude; Savard, Pierre; Dubuc, Isabelle; Flamand, Louis; Farnòs, Omar; Xu, Xingge; Kamen, Amine; Gilbert, Mégan; Rabezanahary, Henintsoa; Scarrone, Martina; Couture, Christian; Baz, Mariana; Leclerc, Denis

A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age

一项随机对照研究,旨在评估一种新型基于rVLP的植物病毒纳米颗粒佐剂联合季节性三价流感疫苗在18-50岁健康成年人单次免疫接种后的安全性和反应原性。

Langley, Joanne; Pastural, Elodie; Halperin, Scott; McNeil, Shelly; ElSherif, May; MacKinnon-Cameron, Donna; Ye, Lingyun; Grange, Cécile; Thibodeau, Valérie; Cailhier, Jean-François; Lapointe, Rejean; McElhaney, Janet; Martin, Luis; Bolduc, Marilène; Laliberté-Gagné, Marie-Eve; Leclerc, Denis; Savard, Pierre

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation.

利用病毒和非病毒瞬时表达快速高产生产功能性SARS-CoV-2受体结合域,用于临床前评估

Farnós Omar, Venereo-Sánchez Alina, Xu Xingge, Chan Cindy, Dash Shantoshini, Chaabane Hanan, Sauvageau Janelle, Brahimi Fouad, Saragovi Uri, Leclerc Denis, Kamen Amine A

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

植物病毒作为基于纳米颗粒的疫苗和佐剂

Lebel, Marie-Ève; Chartrand, Karine; Leclerc, Denis; Lamarre, Alain

Crystal structure of the coat protein of the flexible filamentous papaya mosaic virus

柔性丝状番木瓜花叶病毒外壳蛋白的晶体结构

Yang, Shaoqing; Wang, Tao; Bohon, Jen; Gagné, Marie-Ève Laliberté; Bolduc, Marilène; Leclerc, Denis; Li, Huilin

Improvement of the trivalent inactivated flu vaccine using PapMV nanoparticles.

利用 PapMV 纳米颗粒改进三价灭活流感疫苗

Savard Christian, Guérin Annie, Drouin Karine, Bolduc Marilène, Laliberté-Gagné Marie-Eve, Dumas Marie-Christine, Majeau Nathalie, Leclerc Denis

Palmitoylation of hepatitis C virus core protein is important for virion production

丙型肝炎病毒核心蛋白的棕榈酰化对病毒颗粒的产生至关重要。

Majeau, Nathalie; Fromentin, Rémi; Savard, Christian; Duval, Marie; Tremblay, Michel J; Leclerc, Denis