日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

在肾痨模型中,通过药物或基因手段抑制 CDK5 来缩短纤毛长度可减轻多囊肾病。

Husson, Hervé; Moreno, Sarah; Smith, Laurie A; Smith, Mandy M; Russo, Ryan J; Pitstick, Rose; Sergeev, Mikhail; Ledbetter, Steven R; Bukanov, Nikolay O; Lane, Monica; Zhang, Kate; Billot, Katy; Carlson, George; Shah, Jagesh; Meijer, Laurent; Beier, David R; Ibraghimov-Beskrovnaya, Oxana

Role of TGF-β in a mouse model of high turnover renal osteodystrophy.

TGF-β在小鼠高转换肾性骨营养不良模型中的作用

Liu Shiguang, Song Wenping, Boulanger Joseph H, Tang Wen, Sabbagh Yves, Kelley Brian, Gotschall Russell, Ryan Susan, Phillips Lucy, Malley Katie, Cao Xiaohong, Xia Tai-He, Zhen Gehua, Cao Xu, Ling Hong, Dechow Paul C, Bellido Teresita M, Ledbetter Steven R, Schiavi Susan C

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

GM3合成酶基因缺失(而非鞘氨醇激酶1基因缺失)可预防小鼠肾单位肾痨相关多囊肾病。

Natoli, Thomas A; Husson, Hervé; Rogers, Kelly A; Smith, Laurie A; Wang, Bing; Budman, Yeva; Bukanov, Nikolay O; Ledbetter, Steven R; Klinger, Katherine W; Leonard, John P; Ibraghimov-Beskrovnaya, Oxana

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

一项针对难治性原发性局灶节段性肾小球硬化症的单剂量 fresolimumab 的 1 期研究

Trachtman, Howard; Fervenza, Fernando C; Gipson, Debbie S; Heering, Peter; Jayne, David R W; Peters, Harm; Rota, Stefano; Remuzzi, Giuseppe; Rump, L Christian; Sellin, Lorenz K; Heaton, Jeremy P W; Streisand, James B; Hard, Marjie L; Ledbetter, Steven R; Vincenti, Flavio

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

抑制葡糖基神经酰胺的积累可有效阻断小鼠模型中的多囊肾病。

Natoli, Thomas A; Smith, Laurie A; Rogers, Kelly A; Wang, Bing; Komarnitsky, Svetlana; Budman, Yeva; Belenky, Alexei; Bukanov, Nikolay O; Dackowski, William R; Husson, Hervé; Russo, Ryan J; Shayman, James A; Ledbetter, Steven R; Leonard, John P; Ibraghimov-Beskrovnaya, Oxana

Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury

20-HETE类似物对实验性肾脏缺血再灌注损伤的保护作用

Regner, Kevin R; Zuk, Anna; Van Why, Scott K; Shames, Brian D; Ryan, Robert P; Falck, John R; Manthati, Vijay L; McMullen, Meghan E; Ledbetter, Steven R; Roman, Richard J